Evidence map›Paper›PMID 42653203›Full record

ArticleInternational journal of molecular sciences2026

Refolding Protocol of the Cysteine-Rich Domain of Frizzled8 from Inclusion Bodies.

Ho-Jin Lee, Jie J Zheng

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ho-Jin LeeDepartment of Chemistry, School of Science and Technology, LeMoyne-Owen College, Memphis, TN 38126, USA.ORCID 0000-0002-3251-4984
Jie J ZhengJules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-6524-6800

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Properly folded proteins are essential for studying protein function and developing therapeutic applications. However, when recombinant proteins are overexpressed in bacterial systems such as

Indexed as

CysteineFrizzled ReceptorsInclusion BodiesProtein RefoldingAnimalsChromatography, High Pressure LiquidDisulfidesEscherichia coliMiceProtein DomainsProtein FoldingRecombinant ProteinsCysteineDisulfidesFrizzled ReceptorsRecombinant Proteinscysteine-rich domaindisulfide bondsFrizzled8HPLC purificationinclusion bodiesNMR spectroscopyprotein refoldingsFRP3Wnt signaling

Identifiers

PMID42653203
PMCPMC13513102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.