Evidence map›Paper›PMID 42653177›Full record

ArticleInternational journal of molecular sciences2026

Extracellular Vesicles from Bronchoalveolar Lavage Fluid Indicate Early Biomarker Potential and Differentiate Local Lung Injury in a Porcine Model of Asymmetric Acute Lung Injury.

Benjamin Seybold, Anna Lena Jung, Lynn Feuerbach, Thomas Heimerl, Claudine H Mutschler, Nils Englert, Cleo-Aron Weis, Tanja Poth, Markus A Weigand, Armin Kalenka and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benjamin SeyboldDepartment of Anesthesiology, Heidelberg University Hospital, Medical Faculty, University Heidelberg, 69120 Heidelberg, Germany.ORCID 0009-0003-6110-2713
Anna Lena JungInstitute for Lung Research, Universities of Giesen and Marburg Lung Center, German Center for Lung Research (DZL), Philipps-University Marburg, 35043 Marburg, Germany.ORCID 0000-0002-7762-4597
Lynn FeuerbachInstitute for Lung Research, Universities of Giesen and Marburg Lung Center, German Center for Lung Research (DZL), Philipps-University Marburg, 35043 Marburg, Germany.
Thomas HeimerlCenter for Synthetic Microbiology (SYNMIKRO), Philipps-University Marburg, 35043 Marburg, Germany.
Claudine H MutschlerDepartment of Anesthesiology, Heidelberg University Hospital, Medical Faculty, University Heidelberg, 69120 Heidelberg, Germany.
Nils EnglertTranslational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University Heidelberg, 69120 Heidelberg, Germany.
Cleo-Aron WeisInstitute of Pathology, Heidelberg University Hospital, Medical Faculty, University Heidelberg, 69120 Heidelberg, Germany.
Tanja PothCenter for Model System and Comparative Pathology (CMCP), Heidelberg University Hospital, 69120 Heidelberg, Germany.
Markus A WeigandDepartment of Anesthesiology, Heidelberg University Hospital, Medical Faculty, University Heidelberg, 69120 Heidelberg, Germany.
Armin KalenkaDepartment of Anesthesiology, Heidelberg University Hospital, Medical Faculty, University Heidelberg, 69120 Heidelberg, Germany.
Mascha O Fiedler-KalenkaDepartment of Anesthesiology, Heidelberg University Hospital, Medical Faculty, University Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-0127-2783

Funding

German Center for Lung ResearchHeidelberg University
6 · The paper itself

Abstract

Early detection of acute lung injury (ALI) remains challenging, as conventional diagnostics rarely capture initial molecular changes. We therefore examined whether extracellular vesicles (EVs) in bronchoalveolar lavage fluid (BALF) can detect early regional injury and distinguish initial stress mechanisms in a porcine ALI model. Unilateral ALI was induced using Triton X-100, followed by six hours of mechanical ventilation with either fixed positive end-expiratory pressure (PEEP) at 5 cmH

Indexed as

Acute Lung InjuryBiomarkersBronchoalveolar Lavage FluidExtracellular VesiclesAnimalsDisease Models, AnimalFemaleLungPositive-Pressure RespirationSwineBiomarkersacute lung injuryacute respiratory distress syndromebiomarkerbronchoalveolar lavage fluidextracellular vesiclesporcine model

Identifiers

PMID42653177
PMCPMC13513853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.