ArticleInternational journal of molecular sciences2026
Polygenic Risk Score for Adult Idiopathic Hydrocele Testis: Susceptibility and Severity in a Japanese Cohort.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This exploratory study evaluated whether a polygenic risk score (PRS) derived from a European genome-wide association study is transferable to a Japanese cohort, for both susceptibility to and severity of adult idiopathic hydrocele testis. Surgically confirmed hydrocele cases were compared with two independently ascertained control groups: prostate cancer patients with intraoperatively confirmed absence of hydrocele fluid (Control 1), and urolithiasis patients without malignancy (Stone Control). Multivariable logistic regression evaluated disease occurrence; multiple linear regression restricted to hydrocele cases evaluated the association between PRS and fluid volume. A higher PRS was associated with increased susceptibility to hydrocele when cases were compared with Stone Controls (strictest threshold: odds ratio 1.98, 95% CI 1.01-3.88,
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