Multifunctional Lactoferrin Coatings on PLA/HAp Microspheres for Antibacterial, Pro-Adhesive and Osteogenic Effect on MC3T3-E1 Cells.

Bartosz Mielan, Magdalena Pajączkowska, Joanna Nowicka, Marcel Zambrzycki

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bartosz MielanPre-Clinical Research Centre, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wroclaw, Poland.ORCID 0000-0002-1226-3540

Magdalena PajączkowskaDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubinskiego 4, 50-368 Wroclaw, Poland.ORCID 0000-0002-9881-8294

Joanna NowickaDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Chałubinskiego 4, 50-368 Wroclaw, Poland.ORCID 0000-0002-4001-4189

Marcel ZambrzyckiDepartment of Biomaterials and Composites, Faculty of Materials Science and Technology, AGH University of Kraków, Mickiewicza 30, 30-059 Kraków, Poland.ORCID 0000-0002-7941-426X

Funding

Wroclaw Medical University SUBK.Z516.24.046

6 · The paper itself

Abstract

Modern biomaterials are increasingly expected to fulfill multiple functions simultaneously. The aim of this study was to develop multifunctional composite microspheres (MSs) based on poly(L-lactic acid) and hydroxyapatite (PLA/HAp), surface-modified with lactoferrin (Lf). The objective was to create a material exhibiting antimicrobial, pro-adhesive, and osteogenic properties for potential applications in modular tissue engineering. Microspheres with diameters ranging from 70 to 150 µm were fabricated using an oil-in-water emulsification method and subsequently coated with lactoferrin. Antimicrobial efficacy was evaluated against

Indexed as

Anti-Bacterial AgentsCoated Materials, BiocompatibleDurapatiteLactoferrinMicrospheresOsteogenesisPolyestersAnimalsBacterial AdhesionCandida albicansCell AdhesionCell DifferentiationCell LineMiceOsteoblastsPseudomonas aeruginosaAnti-Bacterial AgentsCoated Materials, BiocompatibleDurapatiteLactoferrinPolyesterspoly(lactide)antimicrobial activitycell adhesioncell carrierslactoferrinmicrospheresmodular tissue engineeringosteogenesispoly(L-lactic acid) (PLA)surface engineering

Identifiers

PMID42653076

DOI10.3390/ijms27167069

PMCPMC13513103

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.