Evidence map›Paper›PMID 42653058›Full record

ReviewLife (Basel, Switzerland)2026

Better Discrimination, Unchanged Practice: Are Machine Learning Models Ready to Replace Established Risk Scores in Cardiac Surgery? A Narrative Review.

Dimitrios E Magouliotis, Serge Sicouri, Vasiliki Androutsopoulou, Prokopis-Andreas Zotos, Massimo Baudo, Basel Ramlawi

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dimitrios E MagouliotisDepartment of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA.ORCID 0000-0001-5417-6392
Serge SicouriDepartment of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA.ORCID 0000-0002-1822-768X
Vasiliki AndroutsopoulouDepartment of Cardiothoracic Surgery, Faculty of Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece.ORCID 0009-0005-2445-0879
Prokopis-Andreas ZotosDepartment of Cardiothoracic Surgery, Faculty of Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece.
Massimo BaudoDepartment of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA.ORCID 0000-0003-3754-6704
Basel RamlawiDepartment of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA.ORCID 0000-0002-0471-0910

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preoperative risk stratification underpins consent, treatment selection, and quality benchmarking in cardiac surgery, a task served for two decades by regression-derived scores such as the European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) and the Society of Thoracic Surgeons Predicted Risk of Mortality (STS PROM), together with procedure-specific tools. A rapidly expanding literature reports that machine learning (ML) models achieve higher discrimination than these scores, yet established scores remain the instruments actually used at the bedside. This narrative review examines that paradox. Drawing on studies emphasized between 2023 and 2026, we argue that the reported advantage of ML is real but modest. This advantage is driven primarily by improved discrimination, while key measures of clinical value, including calibration, net benefit, and external or temporal validation, are infrequently reported. We organize the evidence around a four-lens appraisal (discrimination, calibration, clinical utility, and generalizability) and show that most cardiac surgery ML studies focus only on discrimination. We then consider why superior discrimination has not changed practice and outline the evidence needed for an ML-based risk model to justify replacing an established scoring system. The current literature supports a measured conclusion: ML is a discrimination upgrade in search of clinical proof.

Indexed as

calibrationcardiac surgeryclinical decision supportEuroSCORE IIexternal validationmachine learningrisk predictionSTS score

Identifiers

PMID42653058
PMCPMC13514658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.