ArticleLife (Basel, Switzerland)2026
Effects of Extended-Release Polyhexanide on Inflammatory Cytokine Expression and Disease Severity Following Staphylococcus Aureus Exposure in a Murine Dermatitis Model.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe skin functions as an active immunologic interface in which microbial exposure triggers epithelial stress responses and downstream inflammatory signaling.
objectiveTo evaluate the effects of cutaneous microenvironment modulation using extended-release polyhexanide formulation GX-03 on a murine model of
methodsForty female C57BL/6 mice underwent epicutaneous
resultsGX-03 pretreatment significantly reduced disease severity compared with untreated controls (mean vIGA-AD 0.83 vs. 2.44,
conclusionsPretreatment with extended-release polyhexanide (GX-03) reduced disease severity and was associated with decreased expression of IL-36α, IL-36γ, IL-31, and IL-4 following epicutaneous
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