ArticleLife (Basel, Switzerland)2026
Association of oXiris Hemoadsorption with Inflammatory, Hemodynamic, Respiratory, and Organ Dysfunction Parameters in Patients with Sepsis and Septic Shock in the Intensive Care Unit: A Retrospective Comparative Cohort Study.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
BACKGROUND/
objectivesThis study aimed to evaluate the associations of adding oXiris hemoadsorption therapy to standard sepsis treatment with inflammatory markers, organ dysfunction, hemodynamic parameters, respiratory function, and overall survival (OS) in patients with sepsis and septic shock managed in the intensive care unit (ICU). In our ICU, oXiris was used as adjunctive hemoadsorption for endotoxin and cytokine removal, delivered on a continuous venovenous hemodiafiltration (CVVHDF) platform and initiated independently of acute kidney injury (AKI).
methodsThis retrospective comparative cohort study included 83 adult patients with sepsis or septic shock admitted to the Internal Medicine ICU. Patients were allocated to either the oXiris group (
resultsThe oXiris group had significantly greater baseline clinical severity, including a higher burden of renal dysfunction. This marked baseline imbalance was considered important when interpreting the unadjusted findings and supported the use of adjusted and IPTW analyses. In the oXiris group, CRP, PCT, SOFA-2 score, and norepinephrine requirement showed greater reductions over time, whereas the PaO
conclusionsThe addition of oXiris hemoadsorption to standard sepsis therapy was associated with favorable early temporal changes in organ dysfunction, norepinephrine requirement, and oxygenation. However, the observed CRP and PCT differences were not preserved after IPTW adjustment, and no survival association was identified. These findings should therefore be interpreted as associations rather than evidence of a causal treatment effect.
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