Evidence map›Paper›PMID 42653052›Full record

ReviewLife (Basel, Switzerland)2026

The Value of Transvaginal Neurosonography in the Detection of Fetal Ganglionic Eminence Abnormalities.

Krzysztof Berbeka, Aleksy Świetlicki, Katarzyna Stefańska, Dorota Sys, Dagmara Filipecka-Tyczka, Evelina Bertelli, Manuela Tavares De Sousa, Igor Hawryluk, Magdalena Rudzińska, Sambor Sawicki and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Krzysztof BerbekaFirst Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, ul. Żelazna 90, 01-004 Warsaw, Poland.ORCID 0000-0002-8234-6691
Aleksy ŚwietlickiDepartment of Reproduction, Chair of Fetomaternal Medicine, Poznan University of Medical Sciences, ul. Polna 33, 60-535 Poznan, Poland.ORCID 0000-0001-5855-6114
Katarzyna StefańskaDepartment of Gynecology and Obstetrics, Medical University of Gdansk, ul. Smoluchowskiego 17, 80-952 Gdansk, Poland.
Dorota SysDepartment of Translational Immunology and Experimental Intensive Care, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.ORCID 0000-0002-6829-5947
Dagmara Filipecka-TyczkaFirst Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, ul. Żelazna 90, 01-004 Warsaw, Poland.
Evelina BertelliObstetrics and Gynaecology Department, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy.ORCID 0009-0002-2154-6689
Manuela Tavares De SousaDepartment of Fetal Medicine and Obstetrics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building O10, 20246 Hamburg, Germany.ORCID 0000-0002-2085-7736
Igor HawrylukŻelazna Medical Center, St. Sophia's Specialist Hospital, ul. Żelazna 90, 01-004 Warsaw, Poland.ORCID 0009-0007-2772-7639
Magdalena RudzińskaŻelazna Medical Center, St. Sophia's Specialist Hospital, ul. Żelazna 90, 01-004 Warsaw, Poland.
Sambor SawickiDepartment of Gynecology and Obstetrics, Medical University of Gdansk, ul. Smoluchowskiego 17, 80-952 Gdansk, Poland.
Miriam IllaBCNatal, Fetal Medicine Research Center (Hospital Clinic and Hospital Sant Joan de Déu), Universitat de Barcelona, Carrer de Mejía Lequerica, 39, 08028 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe fetal ganglionic eminence (GE) is a transient brain structure involved in interneuron development; its abnormalities may be associated with malformations of cortical development (MCD). This systematic review evaluated the feasibility and clinical value of transvaginal neurosonography for fetal GE assessment. MATERIAL AND

methodsPubMed, Scopus, and Web of Science were searched from January 2015 to June 2026. Human in vivo ultrasound studies of the fetal GE were included.

resultsThirteen studies comprising 890 fetuses were included. GE visualization ranged from 71% to 100%, with highest rates using dedicated three-dimensional transvaginal neurosonography at 9-22 weeks. Measurement reproducibility was good to excellent. GE cavitation and enlargement were associated with MCD in selected high-risk cohorts, but reported frequencies varied substantially.

conclusionsTransvaginal neurosonography permits feasible and reproducible visualization of the fetal GE in experienced hands. Small studies, heterogeneous protocols, and limited long-term outcome data preclude routine GE assessment at present.

Indexed as

cortical developmentfetal brainganglionic eminenceneurosonographyultrasound

Identifiers

PMID42653052
PMCPMC13514536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.