ArticleLife (Basel, Switzerland)2026
Integrative GWAS Catalog Analysis of Proxy-Trait Intersection in Sarcopenia-Related Musculoskeletal Aging with Multi-Criteria Evidence Integration.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSarcopenia is a multidimensional musculoskeletal-aging phenotype defined by reduced muscle quantity together with weakness and impaired performance, but public genetic resources rarely capture sarcopenia as a single uniformly labeled phenotype.
methodsOfficial National Human Genome Research Institute-European Bioinformatics Institute (NHGRI-EBI) genome-wide association studies (GWAS) Catalog association files archived locally on 15 April 2026 were grouped into muscle-quantity and function-frailty domains. Exact shared rsIDs were identified, assigned to catalog representative/mapped genes, evaluated against exploratory skeletal-muscle transcriptomic context, benchmarked with trait-grouping sensitivity analyses, and ranked with a secondary multi-criteria evidence-integration framework.
resultsThe muscle-quantity domain contained 1580 unique single-nucleotide polymorphisms (SNPs) and the function-frailty domain contained 383 unique SNPs, with 14 exact rsIDs shared between domains. A trait-file permutation benchmark did not show that this overlap exceeded a catalog-level null expectation (empirical
conclusionsThis framework generates candidate hypotheses for sarcopenia-related musculoskeletal aging but does not establish causal, fine-mapped, or statistically enriched genetic sharing.
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