Evidence map›Paper›PMID 42653020›Full record

ReviewLife (Basel, Switzerland)2026

MicroRNA Dysregulation in HPV-Driven Cervical Cancer: A Review of Oncoprotein-Targeted Signaling Pathways.

Geovanna Marques Pereira, Stéphanie Calfa, Pedro Rassier Dos Santos, Ana Julia Aguiar de Freitas, Stefanne Maria Jeha Bortoletto, Rui Manuel Reis, Márcia Maria Chiquitelli Marques, Rhafaela Lima Causin

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Geovanna Marques PereiraMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0009-0006-4886-1733
Stéphanie CalfaMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0002-5278-8720
Pedro Rassier Dos SantosMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Ana Julia Aguiar de FreitasMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0002-9677-2093
Stefanne Maria Jeha BortolettoMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Rui Manuel ReisMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0002-9639-7940
Márcia Maria Chiquitelli MarquesMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0001-5616-6710
Rhafaela Lima CausinMolecular Oncology Research Center, Teaching and Research Institute, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.ORCID 0000-0003-1749-9736

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo #2022/16187-1Fundação de Amparo à Pesquisa do Estado de São Paulo #2024/16601-8Ministry of Health 444011/2023-4
6 · The paper itself

Abstract

MicroRNAs (miRNAs) have been associated with the initiation, development, and progression of various cancers, including cervical cancer. Their involvement in cervical cancer is extensively documented, as they influence critical biological pathways, including apoptosis, cell cycle progression, immune evasion, and metastasis. In cervical cancer, deregulated miRNA expression contributes to tumor aggressiveness by interfering with key molecular pathways, many of which are also influenced by high-risk human papillomavirus (HPV) oncoproteins. In this review, we highlight key signaling pathways regulated by miRNAs linked to cancer hallmarks, particularly sustained proliferative signaling, which was the most frequently affected pathway across the studies reviewed. Furthermore, the interplay among HPV oncoproteins, dysregulated miRNA expression, and altered signaling pathways drives key oncogenic processes, including uncontrolled proliferation, evasion of apoptosis, and metastasis.

Indexed as

cervical cancerhallmarks of cancerHPVmicroRNAssignaling pathways

Identifiers

PMID42653020
PMCPMC13514206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.