ReviewLife (Basel, Switzerland)2026
Toxicity of Some Natural Products in the Treatment of Rheumatoid Arthritis.
Keyla Nunes Farias Gomes, Raíssa Maria Dos Santos Galvão, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, Caroline de Souza Ferreira Pereira, Julianne Soares Pereira, Matheus Amorim Rosa E Silva, Brenda Bairral Queiroz Ornellas, Jonathas Albertino de Souza Oliveira Carneiro, Geovana Espindola Jardim and 3 more
Abstract readReview
In one paragraphReview in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Keyla Nunes Farias GomesPostgraduate Program in Plant Biotechnology and Bioprocesses, Center of Health Sciences, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue 373-University City, Rio de Janeiro 21941-902, RJ, Brazil.
Raíssa Maria Dos Santos GalvãoPostgraduate Program in Science and Biotechnology, Institute of Biology, Fluminense Federal University, Valonguinho Campus, Niterói 24220-900, RJ, Brazil.ORCID 0000-0002-6320-0099 Natalia Lidmar von RankeMolecular Modeling and 3D-QSAR Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, RJ, Brazil.
Carlos Rangel RodriguesMolecular Modeling and 3D-QSAR Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, RJ, Brazil.
Caroline de Souza Ferreira PereiraLaboratory of Environmental Health Assessment and Promotion, Oswaldo Cruz Institute, Av. Brasil 4365, CEP, Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-7089-575X Julianne Soares PereiraPostgraduate Program in Science and Biotechnology, Institute of Biology, Fluminense Federal University, Valonguinho Campus, Niterói 24220-900, RJ, Brazil.
Matheus Amorim Rosa E SilvaPostgraduate Program in Science and Biotechnology, Institute of Biology, Fluminense Federal University, Valonguinho Campus, Niterói 24220-900, RJ, Brazil.
Brenda Bairral Queiroz OrnellasPostgraduate Program in Science and Biotechnology, Institute of Biology, Fluminense Federal University, Valonguinho Campus, Niterói 24220-900, RJ, Brazil.ORCID 0000-0001-6298-6168 Jonathas Albertino de Souza Oliveira CarneiroLaboratory of Environmental Health Assessment and Promotion, Oswaldo Cruz Institute, Av. Brasil 4365, CEP, Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0009-0008-0054-1479 Geovana Espindola JardimLaboratory of Environmental Health Assessment and Promotion, Oswaldo Cruz Institute, Av. Brasil 4365, CEP, Rio de Janeiro 21040-900, RJ, Brazil.
André Lopes FulyPostgraduate Program in Science and Biotechnology, Institute of Biology, Fluminense Federal University, Valonguinho Campus, Niterói 24220-900, RJ, Brazil.ORCID 0000-0002-5265-5258 José Augusto Albuquerque Dos SantosLaboratory of Environmental Health Assessment and Promotion, Oswaldo Cruz Institute, Av. Brasil 4365, CEP, Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0003-0714-4608 Robson Xavier FariaLaboratory of Environmental Health Assessment and Promotion, Oswaldo Cruz Institute, Av. Brasil 4365, CEP, Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-8218-834X Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001FAPERJ E-26/203.246/2017, E-26/010.001861/2019, E-26/211.025/2019National Council for Scientific and Technological Development 308755/2018-9
6 · The paper itselfAbstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects mainly peripheral joints because of inflammation of the synovial membrane. Current treatments, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, although effective, are associated with high costs and several adverse effects. In this context, natural products have emerged as promising alternatives because of their potential therapeutic effects and lower toxicity. The objective of this review was to identify and evaluate natural substances with potential applications in RA treatment on the basis of studies published between 2015 and 2020. A literature search was conducted in SciELO, PubMed, and Google Scholar using the keywords "rheumatoid arthritis", "treatment", "toxicity", and "natural products". Additionally, we applied in silico methods to predict pharmacokinetic and toxicological parameters using ADMET Predictor
Indexed as
in silico analysisnatural productsrheumatoid arthritistoxicitytreatment
Identifiers
PMID42653007
PMCPMC13514934
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