ReviewJournal of clinical medicine2026
Optimizing Vestibular Rehabilitation: From Neuroplastic Mechanisms to Multimodal Therapeutic Strategies.
Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral vestibulopathy (PV) is a common disorder that causes dizziness and balance impairment, substantially affecting patients' quality of life. When symptoms persist, they frequently lead to anxiety, depression, and an increased risk of social isolation. Although central vestibular compensation (CVC) often promotes functional recovery, current pharmacological options remain limited and are primarily aimed at symptom control. Consequently, they should be considered adjuncts rather than alternatives to rehabilitation-based strategies. Vestibular rehabilitation (VR) remains the cornerstone of treatment for promoting functional recovery in patients with PV. Based on the complementary mechanisms of adaptation, substitution, and habituation, VR enhances the central nervous system's ability to compensate for vestibular deficits by optimizing the integration of visual, proprioceptive, and residual vestibular inputs. Robust evidence from both clinical and preclinical studies has demonstrated its efficacy in improving postural stability, dynamic balance, gaze stabilization, and overall functional performance. Experimental studies using animal models have further highlighted the critical role of active sensorimotor training in ecologically relevant environments for enhancing vestibular compensation. Pharmacological interventions may further facilitate these adaptive processes by modulating the neurobiological mechanisms underlying vestibular compensation, thereby improving responsiveness to rehabilitation. Likewise, emerging neuromodulation approaches, including galvanic vestibular stimulation, have shown promising potential to enhance neural plasticity and augment the effects of rehabilitation. Consequently, combining VR with targeted pharmacological therapies and/or vestibular stimulation techniques may provide synergistic benefits and maximize functional recovery. In conclusion, vestibular rehabilitation should remain the foundation of PV management and be integrated with pharmacological and neuromodulatory approaches within a multidisciplinary therapeutic framework. Further research is needed to optimize rehabilitation protocols, identify the biological determinants of successful vestibular compensation, and develop personalized therapeutic strategies aimed at maximizing functional recovery and improving patients' quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.