Evidence map›Paper›PMID 42652445›Full record

ReviewInsects2026

Iron-Sulfur Clusters: A Core Hub in Insect Energy, Reproduction, and Molting.

Xiao-Han Di, Shuo Liu, Duo Wang, Jing-Ze Liu

Abstract readReview
In one paragraph

Review in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao-Han DiMinistry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Research Center of the Basic Discipline of Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China.ORCID 0009-0008-0531-3803
Shuo LiuMinistry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Research Center of the Basic Discipline of Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China.
Duo WangMinistry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Research Center of the Basic Discipline of Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China.
Jing-Ze LiuMinistry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Hebei Research Center of the Basic Discipline of Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China.ORCID 0000-0002-0923-1775

Funding

the Natural Science Foundation of Hebei Province C2025205039
6 · The paper itself

Abstract

Iron-sulfur clusters are a class of functionally diverse protein cofactors. In recent years, significant progress has been made in insect research on iron-sulfur clusters, revealing that they serve as a core molecular hub that integrate multiple physiological processes. This review systematically summarizes the structural characteristics and biosynthetic pathways of iron-sulfur clusters, with an emphasis on insect-specific features in the stability of iron-sulfur cluster assembly proteins, cluster transfer mechanisms, and functional differentiation of ferredoxins. On this basis, it further elucidates the central roles of insect iron-sulfur clusters in energy homeostasis, reproductive capacity, ecdysis, detoxification metabolism, and magnetoreception, and revealed the potential regulatory mechanisms of iron-sulfur proteins in the aforementioned physiological processes in insects, including the electron transport chain, the tricarboxylic acid cycle, the AMPK/TOR signaling axis, cell cycle regulation, and P450 enzyme activity. These findings provide important theoretical foundations and potential molecular targets for the development of environmentally friendly pest control strategies with low resistance risk.

Indexed as

energy metabolisminsect physiologyiron-sulfur clustersmagnetoreceptionmoltingreproduction

Identifiers

PMID42652445
PMCPMC13512959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.