Evidence map›Paper›PMID 42652187›Full record

ArticleBiomedicines2026

Synergy in Dual Engagement of Extrinsic and Intrinsic Apoptosis Pathways by Bleomycin and Panobinostat in Hepatocellular Carcinoma and Targeting Mcl-1-Dependent Apoptosis Resistance.

Patricia Mester, Lena Aschenbrenner, Vlad Pavel, Philipp Heumann, Elisabeth Aschenbrenner, Kirstin Pollinger, Karsten Gülow, Claudia Kunst, Tobias Schilling, Martina Müller

Abstract read
In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patricia MesterDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Lena AschenbrennerDepartment of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, 93053 Regensburg, Germany.
Vlad PavelDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.ORCID 0000-0002-9473-3509
Philipp HeumannDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.ORCID 0009-0005-3803-733X
Elisabeth AschenbrennerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Kirstin PollingerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Karsten GülowDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.ORCID 0009-0006-2897-3447
Claudia KunstDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Tobias SchillingDepartment of Emergency and Intensive Care Medicine, Klinikum Stuttgart, 70174 Stuttgart, Germany.ORCID 0000-0003-1715-6143
Martina MüllerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.ORCID 0000-0002-8520-4568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

apoptosisBcl-2 familyBcl-XLbleomycinhepatocellular carcinoma (HCC)Mcl-1panobinostat

Identifiers

PMID42652187
PMCPMC13509473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.