Evidence map›Paper›PMID 42652065›Full record

ReviewBiomedicines2026

Oxygen Timing as Therapy: Molecular Rationale and Clinical Imperative for Early Oxygen Administration in the Sickle Cell Disease Vaso-Occlusive Crisis-A Structured Narrative Review with Implications for Resource-Constrained Health Systems.

Kanwarjot Singh, Dervens Michaud, Tal Parness, Odinaka Mgbeke, Henry Okodaso, Kwami Jones, Bawo Teddy Ikolo, Shellon Thomas, Felicia Ikolo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kanwarjot SinghSchool of Medicine, Saint George's University, St. George's P.O. Box 7, Grenada.
Dervens MichaudSchool of Medicine, Saint George's University, St. George's P.O. Box 7, Grenada.ORCID 0009-0005-6668-9036
Tal ParnessSchool of Medicine, Saint George's University, St. George's P.O. Box 7, Grenada.
Odinaka MgbekeDepartment of Clinical Skills, School of Medicine, Saint George's University, St. George's P.O. Box 7, Grenada.ORCID 0009-0007-9459-176X
Henry OkodasoDepartment of Anatomical Sciences, School of Medicine, Saint George's University KBT Global Scholars Program, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Kwami JonesDepartment of Biochemistry, School of Medicine, Saint George's University, St. George's P.O. Box 7, Grenada.
Bawo Teddy IkoloDepartment of Biology, Ecology & Conservation, School of Arts and Sciences, Saint George's University, St. George's P.O. Box 7, Grenada.
Shellon ThomasDepartment of Biochemistry, School of Medicine, Saint George's University, St. George's P.O. Box 7, Grenada.ORCID 0009-0008-2575-5748
Felicia IkoloSickle Cell Association of Grenada, St. George's P.O. Box 436, Grenada.ORCID 0000-0002-7711-903X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease (SCD) is a monogenic hemoglobinopathy in which hemoglobin S (HbS) polymerizes on deoxygenation, leading to sickling of red blood cells (RBCs) and driving the acute vaso-occlusive crisis (VOC). With curative (transformative) therapies inaccessible to most patients in sub-Saharan Africa and the Caribbean, where burden is highest, optimizing acute VOC care is a priority; yet oxygen is given reactively, after hypoxemia is documented, not at symptom onset when polymerization is most interruptible. We conducted a structured narrative review integrating HbS polymerization kinetics, clinical studies of oxygen-based therapies, trial protocols, and home-care implementation evidence (PubMed, Scopus, Google Scholar; 1974-2026). When RBCs release oxygen, HbS does not solidify at once: a brief pause, the nucleation delay phase (t

Indexed as

Caribbean health systemsDREPADOMearly interventiongolden half hourhealth equityhemoglobin S polymerizationnucleation delay phaseoxygen therapysickle cell diseasevaso-occlusive crisis

Identifiers

PMID42652065
PMCPMC13509722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.