Evidence map›Paper›PMID 42652025›Full record

ArticleAnimals : an open access journal from MDPI2026

Effects of Dietary Sterol-Rich Yeast Hydrolysate on Serum Lipid Indices, Intestinal Morphology, Digestive Enzyme Activities, Barrier-Related Gene Expression, and Cecal Microbiota in Yellow-Feathered Broiler Breeder Hens.

Yining Zhang, Zhifang Shi, Mengyun Li, Haoran Si, Bo Fan, Xuanyang Li, Yongzhen Li, Xiaotong Wang, Jian Liu, Lei Xi

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yining ZhangCollege of Animal Science, Xinjiang Agricultural University, No. 311 Nongda East Road, Urumqi 830052, China.ORCID 0009-0007-7572-9233
Zhifang ShiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, No. 6 Longzihu North Road, Zhengzhou 450046, China.ORCID 0000-0001-7122-6523
Mengyun LiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, No. 6 Longzihu North Road, Zhengzhou 450046, China.
Haoran SiCollege of Animal Science, Xinjiang Agricultural University, No. 311 Nongda East Road, Urumqi 830052, China.
Bo FanCollege of Animal Science, Xinjiang Agricultural University, No. 311 Nongda East Road, Urumqi 830052, China.ORCID 0009-0002-2619-2090
Xuanyang LiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, No. 6 Longzihu North Road, Zhengzhou 450046, China.
Yongzhen LiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, No. 6 Longzihu North Road, Zhengzhou 450046, China.
Xiaotong WangCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, No. 6 Longzihu North Road, Zhengzhou 450046, China.
Jian LiuCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, No. 6 Longzihu North Road, Zhengzhou 450046, China.
Lei XiCollege of Animal Science, Xinjiang Agricultural University, No. 311 Nongda East Road, Urumqi 830052, China.

Funding

National Key Research and Development Program of China 2023YFD1300804-2
6 · The paper itself

Abstract

This study evaluated dietary sterol-rich yeast hydrolysate (SYH) at 0, 0.2, 0.5, and 0.8 g/kg in 720 yellow-feathered broiler breeder hens for 6 weeks. The tested SYH, supplied as a powder, contained 9.24% mannan, 3.1% total sterols, 2.0% amino nitrogen, and 3.64 g/kg nucleotides. Serum lipoproteins, intestinal morphology, digestive enzyme activities, barrier-related gene expression, and cecal microbiota were assessed. Low-density lipoprotein cholesterol was higher in J-C than in Control, J-A, and J-B, whereas high-density lipoprotein cholesterol did not differ among treatments. Duodenal lipase showed a significant overall treatment effect, but no Dunn-Holm pairwise comparison remained significant; ileal lipase was higher in J-C than in J-A. For barrier-related transcripts, J-A had higher ZO-1 than the Control and J-B and higher occludin and claudin-1 than all other groups, whereas MUC2 was higher in J-A and J-C than in the Control. These transcript changes are consistent with the modulation of molecular components associated with intestinal barrier integrity, but they do not by themselves demonstrate improved barrier function. Intestinal morphology showed selective, segment-specific differences rather than a consistent dose-related pattern. Alpha diversity did not differ, whereas Bray-Curtis PERMANOVA detected an overall difference among treatments (

Indexed as

barrier-related gene expressioncecal microbiotadigestive enzymeintestinal morphologyserum lipidsterol-rich yeast hydrolysateyellow-feathered broiler breeder hen

Identifiers

PMID42652025
PMCPMC13509503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.