ArticleAnimals : an open access journal from MDPI2026
In-Life Testicular Volume as an Indicator of Histological Testicular Development Suitable for Testicular Toxicity Evaluation in Male Cynomolgus Macaques (
Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Reliable evaluation of testicular toxicity in nonclinical safety studies requires animals with sufficient histological testicular maturity. However, chronological age alone is an unreliable indicator of reproductive maturity in cynomolgus macaques because substantial inter-individual variation exists in pubertal development. Since histological maturity can only be confirmed after necropsy, a practical, non-invasive method for prospective animal selection is needed. This retrospective study evaluated whether in-life testicular volume could predict histological maturity suitable for routine histopathological evaluation. Testicular length and width were measured immediately before scheduled necropsy in 61 male cynomolgus macaques (
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