Evidence map›Paper›PMID 42651923›Full record

ArticleAnimals : an open access journal from MDPI2026

Dietary Bile Acid Supplementation Improves Lipid Metabolism and Selected Egg Quality Traits in Late-Phase Laying Hens Fed a High-Fat Diet and Is Associated with Alterations in Gut Microbiota.

Cai Ma, Mingzhi Liang, Zengguang Wang, Guanghui Teng, Junhai Xue, Jie Ma, Ruili Li, Ming Qin

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cai MaDepartment of Medical Genetics and Cell Biology, Shandong Medical and Pharmaceutical University, Yantai 264003, China.
Mingzhi LiangInstitute of Animal Science and Veterinary Medicine, Yantai Academy of Agricultural Sciences, Yantai 265500, China.
Zengguang WangInstitute of Animal Science and Veterinary Medicine, Yantai Academy of Agricultural Sciences, Yantai 265500, China.
Guanghui TengCollege of Water Resources & Civil Engineering, China Agricultural University, Beijing 100083, China.
Junhai XueYantai Jinlai Food Co., Ltd., Yantai 261413, China.
Jie MaYantai Jinlai Food Co., Ltd., Yantai 261413, China.
Ruili LiInstitute of Animal Science and Veterinary Medicine, Yantai Academy of Agricultural Sciences, Yantai 265500, China.
Ming QinInstitute of Animal Science and Veterinary Medicine, Yantai Academy of Agricultural Sciences, Yantai 265500, China.

Funding

Key R&D Program of Shandong Province, China No. 2022TZXD0015Shandong Provincial Natural Science Foundation No. ZR2025QC231
6 · The paper itself

Abstract

High-fat diets may improve energy supply in laying hens, but they can also increase fat deposition in the liver and contribute to fatty liver hemorrhagic syndrome (FLHS), a metabolic disorder that impairs hen health and egg production. Bile acids (BAs), which are natural compounds produced in the liver to support fat digestion and metabolic regulation, may help reduce these negative effects. This study evaluated the effects of dietary BA supplementation on production performance, selected egg quality traits, lipid-related indices, liver histology, and cecal microbiota in late-phase laying hens fed a high-fat diet (HFD). A total of 150 Hy-Line Brown laying hens at 50 weeks of age were allocated either a normal diet (ND), a HFD, or a HFD supplemented with 300 mg/kg BAs (HFD + BAs) for 5 weeks. Compared with the HFD group, BA supplementation affected average daily feed intake (ADFI) and increased the Haugh unit (HU) (

Indexed as

bile acidfatty liver hemorrhagic syndromegut microbiotalaying henslipid metabolism

Identifiers

PMID42651923
PMCPMC13508983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.