ArticleAnimals : an open access journal from MDPI2026
Genome-Wide Association Study and Genomic Selection for Average Daily Gain in Ashidan Yak.
Zhicheng Wang, Xiaoming Ma, Guangwei Hu, Jianwu Jing, Yongfu La, Wenwen Ren, Baicheng Zhou, Hongkang Li, Min Chu, Xiaoyun Wu and 3 more
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In one paragraphArticle in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
Zhicheng WangKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0009-0006-0032-1308 Xiaoming MaKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Guangwei HuQinghai Province Yak Breeding and Promotion Service Center, Xining 810100, China.
Jianwu JingQinghai Province Yak Breeding and Promotion Service Center, Xining 810100, China.
Yongfu LaKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0000-0002-5659-4341 Wenwen RenKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0009-0002-2838-3616 Baicheng ZhouQinghai Province Yak Breeding and Promotion Service Center, Xining 810100, China.
Hongkang LiQinghai Province Yak Breeding and Promotion Service Center, Xining 810100, China.
Min ChuKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Xiaoyun WuKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Ping YanKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Xian GuoKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0000-0003-2390-4777 Chunnian LiangKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Funding
Gansu Province Talent Program 2026RCXM096Qinghai Province Key Research and Transformation Program 2025-QY-201the Modern Beef Yak Industry Technology System, grant number MATS-Beef Cattle System CARS-37The Project for Collecting and Evaluating Sample Data of Livestock and Poultry Genetic Resources of the Department of Agriculture and Rural Affairs of Gansu GSZYTC-ZX-26048
6 · The paper itselfAbstract
Average daily gain (ADG) is a core quantitative trait determining the economic benefits of Ashidan yak, a polled new breed adapted to cold barn feeding on the Qinghai-Tibet Plateau. Unraveling its complex genetic architecture is crucial for early molecular breeding selection. In this study, high-depth whole-genome resequencing (WGS) data from 474 Ashidan yaks were used to conduct combined evaluation of genome-wide association study (GWAS) and genomic selection (GS). During GWAS analysis, sex and measurement batch were included as fixed effects, while birth weight and principal components (PC1-PC3) were incorporated as covariates. Multi-model association analysis using GLM, MLM, and FarmCPU was performed on 3.36 million LD-pruned SNPs. The genomic inflation factors (λ ≈ 1.0) for MLM and FarmCPU confirmed effective elimination of population stratification. A total of 11 genome-wide significant SNP loci and 7 key candidate genes including
Indexed as
Ashidan yakaverage daily gaincandidate genesgenome-wide association studygenomic selectionwhole-genome resequencing
Identifiers
PMID42651857
PMCPMC13508993
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