Evidence map›Paper›PMID 42651835›Full record

ReviewCurrent issues in molecular biology2026

Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders.

Mohammad Sadegh Shams Nosrati, Morteza Doustmohammadi, Alireza Dostmohammadi, Armita Kakavand Hamidi, Mahsa Boogari, Zahra Hoseini Tavassol, Shakiba Khosravinejat, Majid Asgari, Morvarid Shafiei, Amir Hesam Nemati and 10 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mohammad Sadegh Shams NosratiMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Morteza DoustmohammadiMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran P.O. Box 14117-13135, Iran.ORCID 0009-0009-8557-1673
Alireza DostmohammadiDepartment of Bioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, 45141 Essen, Germany.ORCID 0000-0003-4311-2056
Armita Kakavand HamidiMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran P.O. Box 14117-13135, Iran.ORCID 0000-0003-3135-9879
Mahsa BoogariDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran P.O. Box 14618-84513, Iran.ORCID 0009-0007-8638-1076
Zahra Hoseini TavassolEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran P.O. Box 14117-13135, Iran.ORCID 0000-0002-2432-2114
Shakiba KhosravinejatResearch Center, Alborz University of Medical Sciences, Karaj 3198764653, Iran.
Majid AsgariMyeloma Center, Winthrop P. Rockefeller Institute, Department of Internal Medicine, University of Arkansas for Medical Science, Little Rock, AR 72205, USA.
Morvarid ShafieiDepartment of Bacteriology, Pasteur Institute of Iran, Tehran P.O. Box 13169-43551, Iran.
Amir Hesam NematiDepartment of Epidemiology and Biostatistics, Pasteur Institute of Iran, Tehran P.O. Box 13169-43551, Iran.
Ferruccio RomanoGenomic and Clinical Genetics Unit, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Valeria CapraGenomic and Clinical Genetics Unit, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-3097-0388
Bruno SterliniDipartimento di Medicina Sperimentale, Università di Genova, 16132 Genoa, Italy.ORCID 0000-0001-8247-4709
Mohammad DarbalaeiDepartment of Bioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, 45141 Essen, Germany.
Mohammad SalehiWest German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Mir Davood OmraniDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 1985717443, Iran.ORCID 0000-0002-0673-9717
Federico ZaraMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Zoha KibarAzrieli Research Center of CHU Sainte Justine, University of Montreal, Montreal, QC H3T 1C5, Canada.
Tatsuo MiyamotoDivision of Advanced Genome Editing Therapy Research, Research Institute for Cell Design Medical Science, Yamaguchi University, Ube 755-8503, Japan.ORCID 0000-0002-1097-0647
Marcello ScalaMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0003-2194-7239

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and maintenance of the nervous system depend on a tightly regulated intracellular transport network in which kinesin superfamily (KIF) motor proteins drive microtubule-based delivery of synaptic vesicle precursors, organelles, mRNAs, and signaling components along axons and dendrites. Disruption of this machinery underlies a clinically heterogeneous spectrum of neurodevelopmental disorders (NDDs), including intellectual disability, epilepsy, autism spectrum disorder, microcephaly, malformations of cortical development, spasticity, and axonal neuropathy. Here, we synthesize current knowledge on how kinesin dysfunction shapes neurodevelopment. We outline the physiological roles of kinesins in neuronal polarity, organelle and mitochondrial positioning, synaptogenesis, and progenitor division, and survey principal disease-associated genes, including

Indexed as

axonal transportKIF1AKIF5AKIF motor proteinskinesinopathieskinesinsmicrotubulesneurodevelopmental disordersneuronal migrationprecision medicine

Identifiers

PMID42651835
PMCPMC13510395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.