Evidence map›Paper›PMID 42651832›Full record

ArticleCurrent issues in molecular biology2026

Pinoresinol as a Potential c-Myc Complex Modulator: An In Silico Study.

Arnulfo Villanueva-Castillo, Claudia Mancilla-Simbro, Fernando Villa-Diaz, Alberto Ramírez-Mata, Cesar F Pastelín-Rojas, Ruby S Moreno-Mejía, Hermilo Lucio-Castillo, Briseida L Castro-Bautista, Carlos G Castillo-Sosa, Fátima Matamoros-González and 9 more

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Arnulfo Villanueva-CastilloCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.ORCID 0000-0002-9430-1503
Claudia Mancilla-SimbroHybridLab.Physiology and Molecular Biology of Excitable Cells, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 sur 6301, CU San Manuel, Puebla 72570, Puebla Pue., Mexico.ORCID 0000-0003-3976-3550
Fernando Villa-DiazLaboratorio de Simulaciones Moleculares Computacionales, Tecnológico Nacional de México, Campus Guaymas, Carretera al Varadero Nacional, Las Playitas, Guaymas 85480, Sonora, Mexico.ORCID 0000-0002-1118-5579
Alberto Ramírez-MataLaboratorio de la Interacción Bacteria-Planta, Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias (ICUAP), Benemérita Universidad Autónoma de Puebla, Building 103J, Av. San Claudio S/N, San Manuel Colony, Puebla 72570, Puebla Pue., Mexico.ORCID 0000-0002-2119-2254
Cesar F Pastelín-RojasCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.ORCID 0000-0002-9501-2017
Ruby S Moreno-MejíaCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.ORCID 0009-0004-7888-9839
Hermilo Lucio-CastilloUnidad Académica Multidisciplinaria Mante, Universidad Autónoma de Tamaulipas. Blvd. Enrique Cárdenas González No. 1201 Pte. Ciudad Mante, El Mante 89840, Tamaulipas, Mexico.
Briseida L Castro-BautistaCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.
Carlos G Castillo-SosaCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.ORCID 0000-0002-5742-7772
Fátima Matamoros-GonzálezCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.
Alexis Cruz-EspinosaCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.
Angélica Abascal-GrajalesCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.
Mónica A Olea-AmezcuaFacultad de Artes Plásticas y Audiovisuales, Benemérita Universidad Autónoma de Puebla, Vía Atlixcáyotl No. 2499, Complejo Cultural Universitario, Reserva Territorial Atlixcáyotl Colony, Puebla 72810, Puebla Pue., Mexico.ORCID 0000-0001-8649-7748
Evili Báez CastilloCentro de Estudios "Justo Sierra", Badiraguato 80600, Sinaloa, Mexico.ORCID 0000-0002-1048-3734
Laura G Hernández-AragónLab de Cáncer y Comunicación Intercelular, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 sur 6301 CU San Manuel, Colony Los Volcanes, Puebla 72570, Puebla Pue., Mexico.ORCID 0000-0001-6248-0562
Alejandra Escobar NoriegaAcademia de Fisiología, Facultad de Medicina-, Benemérita Universidad Autónoma de Puebla, Calle 13 Sur 2706, Centro Colony, Puebla 72410, Puebla Pue., Mexico.ORCID 0000-0003-2613-3453
Sandra R Reyes CarmonaLaboratorio de la Interacción Bacteria-Planta, Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias (ICUAP), Benemérita Universidad Autónoma de Puebla, Building 103J, Av. San Claudio S/N, San Manuel Colony, Puebla 72570, Puebla Pue., Mexico.ORCID 0000-0002-1015-5079
Fernando Utrera QuintanaCuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274, Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 4 Sur 304 Centro Colony, Tecamachalco 75482, Puebla Pue., Mexico.ORCID 0000-0002-5203-0661
Sagrario Lobato HuertaCentro de Estudios "Justo Sierra", Badiraguato 80600, Sinaloa, Mexico.ORCID 0000-0001-8220-6819

Funding

Bioinformática Inclusiva: discapacidad visual. HybridLab.Physiology and Molecular Biology of Excitable Cells, Instituto de Fisiología. Benemérita Universidad Autónoma de Puebla VIEP-25073Laboratorio Nacional de Supercómputo del Sureste de México-DCyTIC. Vicerrectoría de Investigación y Estudios de Posgrado, Proyecto VIEP 00435-PV/2024the Faculty of Veterinary Medicine and Zootechnics, Benemérita Universidad Autónoma de Puebla, and Cuerpo Académico de Enfermedades Emergentes, Bioinformática y Dinámica Molecular CA-BUAP-274
6 · The paper itself

Abstract

The c-Myc oncoprotein is a central regulator of oncogenic transcriptional programs that remains challenging to inhibit directly, necessitating strategies that target c-Myc-associated protein complexes rather than the protein alone. This study conducted an in silico evaluation of the natural biphenolic lignan pinoresinol as a potential modulator of the c-Myc-TBP-TAF1 (TATA-binding protein (TBP)- Multiple direct interactions of TBP with the MYC oncoprotein) transcriptional complex (PDB ID: 6E16). Prior to molecular docking, the protein structure was subjected to energy minimization using the AMBER ff14SB force field to optimize conformational stability and structural reliability; ligand preparation and docking were performed with standard, widely used tools (e.g., AutoDock Vina v1.1.2; visualization and interface analyses in UCSF Chimera/ChimeraX and SeamDock). Molecular docking and binding-interface analyses identified reproducible interactions within defined pockets P

Indexed as

AMBER analysisc-Myc oncoproteinmolecular dockingpinoresinol

Identifiers

PMID42651832
PMCPMC13511002

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