Evidence map›Paper›PMID 42651768›Full record

ArticleCurrent issues in molecular biology2026

Lipid-Laden M1-like Macrophages of Familial Hypercholesterolemia Patients Are Characterized by Increased Interleukin-1β Secretion and Reduced

Artem Izyumchenko, Tatiana Usenko, Kseniia Dracheva, Kristina Legostaeva, Soreiia Urazgildeeva, Kseniia Tanayants, Maria Grunina, Ekaterina Larionova, Pavel Suchko, Oleg Glotov and 3 more

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Artem IzyumchenkoDepartment of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, Russia.ORCID 0000-0003-2919-1878
Tatiana UsenkoDepartment of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, Russia.ORCID 0000-0002-5132-2283
Kseniia DrachevaDepartment of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
Kristina LegostaevaDepartment of Propaedeutics of Internal Diseases, Pavlov First Saint Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
Soreiia UrazgildeevaSaint-Petersburg Medical and Social Institute, 195271 Saint-Petersburg, Russia.ORCID 0000-0003-3046-372X
Kseniia TanayantsPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 188300 Gatchina, Russia.
Maria GruninaDepartment of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
Ekaterina LarionovaFederal State Budgetary Research Institution "Institute of Experimental Medicine", 197022 Saint-Petersburg, Russia.ORCID 0009-0006-8413-1412
Pavel SuchkoCentre for Genomic Technologies Cerbalab, 199106 Saint-Petersburg, Russia.ORCID 0009-0000-7015-1208
Oleg GlotovCentre for Genomic Technologies Cerbalab, 199106 Saint-Petersburg, Russia.ORCID 0000-0002-0091-2224
Alexandr KulikovDepartment of Propaedeutics of Internal Diseases, Pavlov First Saint Petersburg State Medical University, 197022 Saint-Petersburg, Russia.
Sofya PchelinaDepartment of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, Russia.ORCID 0000-0001-7431-6014
Valentina MiroshnikovaDepartment of Molecular Genetic and Nanobiological Technologies, Pavlov First Saint-Petersburg State Medical University, 197022 Saint-Petersburg, Russia.ORCID 0000-0003-3160-2314

Funding

Russian Science Foundation 25-25-00351
6 · The paper itself

Abstract

Familial hypercholesterolemia (FH) is a common hereditary dyslipidemia characterized by high levels of low-density lipoprotein (LDL) cholesterol and a risk of premature atherosclerosis. Previous studies showed that cardiovascular risks persist in FH even after hypolipidemic therapy is started and are linked to a proinflammatory status of circulating monocytes. In the current study we aimed to identify FH-specific gene expression patterns of monocyte-derived M1-like macrophages in response to lipid accumulation. RNAseq was performed for four patient and four control paired samples of M1-like macrophages before and after incubation with oxidized LDL (oxLDL). A validation step was performed in 10 patients and 10 controls using real-time PCR and ELISA. RNAseq data analysis revealed 22 DEGs between FH patients and the control group before and 47 DEGs after incubation with oxLDL. Pathway enrichment analysis suggested dysregulation of inflammatory pathways especially IL-1 and chemokine signaling in response to lipid accumulation in FH M1-like macrophages. Validation experiments demonstrated increased interleukin-1β secretion by lipid-laden M1-like macrophages in FH patients and reduced

Indexed as

chemokine signalingfamilial hypercholesterolemiainflammasomeinterleukin-1βM1-like macrophagesRNAseqTMEM176

Identifiers

PMID42651768
PMCPMC13511675

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