Evidence map›Paper›PMID 42651749›Full record

ArticleCurrent issues in molecular biology2026

Distinct Transcriptomic Signatures of HIV-1 Tat and gp120 Uncover Differential Neuroimmune Vulnerability in a

Anna Lagni, Virginia Lotti, Erica Diani, Riccardo Cecchetto, Stefania Turrina, Dario Raniero, Asia Palmisano, Annarita Mazzariol, Davide Gibellini, Giovanna Paolone

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In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna LagniDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.ORCID 0009-0005-1044-3109
Virginia LottiDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-5746-3810
Erica DianiDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-1373-7533
Riccardo CecchettoDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.ORCID 0009-0000-5189-8867
Stefania TurrinaDepartment of Diagnostics and Public Health, Section of Forensic Medicine, University of Verona, 37134 Verona, Italy.
Dario RanieroDepartment of Diagnostics and Public Health, Section of Forensic Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-0468-8602
Asia PalmisanoDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.
Annarita MazzariolDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-2729-1007
Davide GibelliniDepartment of Diagnostics and Public Health, Section of Microbiology, University of Verona, 37134 Verona, Italy.
Giovanna PaoloneDepartment of Diagnostics and Public Health, Section of Pharmacology, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-4484-5529

Funding

Ministry of Universities and Research 2022NXK38S
6 · The paper itself

Abstract

HIV-associated neurocognitive disorders (HAND) persist despite effective antiretroviral therapy, indicating that chronic neuroimmune dysfunction extends beyond active viral replication. Among HIV-1-derived factors, the viral proteins Tat and gp120 are contributors to sustained brain inflammation. Nevertheless, their comparative impact in genetically vulnerable neural environments remains unclear. Here, we performed a secondary transcriptomic analysis of publicly available RNA-seq data derived from the striatal tissue of h

Indexed as

Gba1 L444Pgp120HIV-1neuroinflammationnigrostriatal dysfunctionParkinson’s diseaseTat

Identifiers

PMID42651749
PMCPMC13510770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.