Evidence map›Paper›PMID 42651680›Full record

ArticleBiology2026

Effects of Valproate and Deferoxamine on Epileptiform Activity, Oxidative Stress, and Nitric Oxide in a Penicillin-Induced Epilepsy Model.

Arzuhan Çetindağ, Şeyma Özsoy, Levent Hacisüleyman, Ziya Çakir, Elif Azize Özşahin Delibaş

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arzuhan ÇetindağVocational School of Health Services, Sivas Cumhuriyet University, 58140 Sivas, Türkiye.ORCID 0000-0002-5420-3546
Şeyma ÖzsoyDepartment of Physiology, Faculty of Medicine, Tokat Gaziosmanpasa University, 60100 Tokat, Türkiye.ORCID 0000-0003-1783-3618
Levent HacisüleymanDepartment of Pharmacology, Faculty of Pharmacy, Fenerbahçe University, 34758 Istanbul, Türkiye.ORCID 0000-0002-4374-9025
Ziya ÇakirDepartment of Oral and Dental Health, Faculty of Health Services Vocational School, Tokat Gaziosmanpasa University, 60100 Tokat, Türkiye.ORCID 0009-0003-0329-1974
Elif Azize Özşahin DelibaşDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Tokat Gaziosmanpasa University, 60100 Tokat, Türkiye.ORCID 0000-0002-4195-0884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative and nitrosative stress contribute to epileptogenesis and seizure-related neuronal injury through iron-mediated reactive oxygen species generation and excessive nitric oxide production. This study examined whether combining valproate (VALP) with the iron chelator deferoxamine (DFO) produces additional electrophysiological or biochemical effects in a penicillin-induced model of epileptiform activity. Male Wistar rats were assigned to four groups (

Indexed as

deferoxamineelectrocorticographyepilepsynitric oxideoxidative stressvalproate

Identifiers

PMID42651680
PMCPMC13510096

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.