ReviewBiology2026
Molecular Mechanisms of Vasculogenesis in Human Cancers: From Developmental Pathways to Tumor Vascular Remodeling and Therapeutic Targeting.
Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
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Abstract
Vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells, is increasingly recognized as a critical contributor to tumor vascularization, complementing classical angiogenesis and promoting cancer progression, metastasis, therapeutic resistance, and disease recurrence. This narrative review aims to provide a comprehensive overview of the molecular mechanisms governing vasculogenesis across human malignancies and to discuss their translational relevance for targeted cancer therapy. This is a narrative, mechanistically oriented review rather than a systematic review or meta-analysis. The literature was searched in PubMed, Scopus, and Google Scholar, with the primary search covering publications from January 2010 to February 2026, while seminal earlier studies were included when they established fundamental concepts in vascular biology. Search terms included combinations of "vasculogenesis", "tumor vasculogenesis", "angiogenesis", "endothelial progenitor cells", "vascular remodeling", "VEGF", "HIF-1α", "Notch", "Wnt", "PI3K/AKT", "TGF-β", "EndMT", "mechanotransduction", "non-coding RNAs", "tumor microenvironment", and "cancer". Evidence was qualitatively appraised and synthesized according to mechanistic relevance and consistency across experimental and clinical studies. The reviewed literature highlights the complex interplay between developmental signaling pathways, endothelial plasticity, mechanical cues, inflammatory mediators, and non-coding RNAs in regulating tumor vasculogenesis. Collectively, these findings suggest that targeting vasculogenesis-related pathways may complement existing anti-angiogenic therapies and represent a promising strategy for improving precision oncology and overcoming treatment resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.