Evidence map›Paper›PMID 42651283›Full record

ReviewHealthcare (Basel, Switzerland)2026

Multidisciplinary Strategies to Manage Treatment-Related Dermatologic Toxicity and Improve Quality of Life in Cancer Patients: A Narrative Review.

Joaquim Faria Monteiro, Clémence Salvador-Entradas, Dorian Marrot, Maribel Teixeira, Nuno Milhazes, Vera Almeida, Ana Teixeira

Abstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joaquim Faria MonteiroUCIBIO, Applied Molecular Biosciences Unit, i4HB, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal.ORCID 0000-0002-1635-8811
Clémence Salvador-EntradasUniversity Institute of Health Sciences IUCS, CESPU, CRL, 4585-116 Gandra, Portugal.ORCID 0009-0002-9481-5579
Dorian MarrotUniversity Institute of Health Sciences IUCS, CESPU, CRL, 4585-116 Gandra, Portugal.ORCID 0009-0000-3124-8576
Maribel TeixeiraAssociate Laboratory i4HB, Institute for Health and Bioeconomy, University Institute of Health Sciences, CESPU, 4585-116 Gandra, Portugal.ORCID 0000-0003-3989-9474
Nuno MilhazesAssociate Laboratory i4HB, Institute for Health and Bioeconomy, University Institute of Health Sciences, CESPU, 4585-116 Gandra, Portugal.ORCID 0000-0002-5171-0454
Vera AlmeidaUCIBIO, Applied Molecular Biosciences Unit, i4HB, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal.ORCID 0000-0003-2803-8038
Ana TeixeiraUCIBIO, Applied Molecular Biosciences Unit, i4HB, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal.ORCID 0000-0002-3254-5326

Funding

Cooperativa de Ensino Superior Politécnico e Universitário ONCOCARE-GI2-CESPU-2025
6 · The paper itself

Abstract

BACKGROUND/

objectivesDermatologic toxicities are among the most common adverse effects of anticancer therapies, including chemotherapy, targeted therapies, and immunotherapies. Although typically non-life-threatening, these conditions can significantly impair quality of life, alter body image, and lead to treatment non-adherence which may compromise health outcomes. This systematic review aims to synthesize the evidence on the incidence, severity, and management of treatment-related dermatologic toxicities, with a focus on pharmaceutical and multidisciplinary care strategies.

methodsThis review followed the PRISMA 2020 guidelines. PubMed, ScienceDirect, and Cochrane were searched for studies published between 1 January 2015 and 31 December 2025. Eligibility criteria were defined using the PICO (R) framework. Study selection, data extraction, and risk-of-bias assessment were performed independently by two reviewers. Given study heterogeneity, a narrative synthesis was conducted.

resultsSeventeen studies were included. Dermatologic toxicities were frequently reported during cancer treatment and were generally mild to moderate in severity, although they imposed a substantial burden on patients. Supportive dermatologic care strategies were associated with reduced symptom severity and improved quality of life in some studies. Evidence for pharmaceutical care and multidisciplinary management was more limited, and the available data do not allow firm conclusions regarding their effectiveness.

conclusionsDermatologic toxicities remain an important challenge in oncological care. The evidence suggests potential benefits of supportive care approaches, but the certainty of the evidence is limited, particularly for pharmaceutical care. Further high-quality studies are needed to clarify the impact of these interventions and support standardized recommendations.

Indexed as

adherence to treatmentbody imagecancer treatmentdermatologic toxicitypharmaceutical carequality of life

Identifiers

PMID42651283
PMCPMC13512126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.