ArticleHealthcare (Basel, Switzerland)2026
Life-Stage Differences in the Longitudinal Associations of Multimorbidity Profiles with Economic Burden, Health-Related Quality of Life, and Inpatient Utilization.
Article in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesMultimorbidity is associated with substantial healthcare burdens, but its associations with health and economic outcomes among young adults remain poorly characterized. This study examined associations between clinically defined multimorbidity profiles and expenditures, catastrophic healthcare expenditure, health-related quality of life, and inpatient utilization across adult life stages.
methodsMedical Expenditure Panel Survey Panel 24 data were analyzed for 4331 U.S. adults followed from 2019 through 2022, including 942 young adults. Respondents were classified into five profiles: no included conditions, respiratory only, cardiometabolic only, any-cancer involved, and cardiorespiratory. Longitudinally weighted generalized estimating equations were fitted.
resultsProfile distribution differed significantly across age groups. Among young adults, overall profile and profile-by-year tests were nonsignificant for total expenditures and most other outcomes. In 2019, the cardiorespiratory profile was associated with higher expected expenditures than no included conditions (expenditure ratio = 3.44, 95% CI: 1.59-7.46;
conclusionsOverall profile effects were not consistently demonstrated among young adults. Parameter-specific cardiorespiratory estimates suggested a potentially elevated burden but remained exploratory because of sparse observations and nonsignificant overall tests. Socioeconomic vulnerability remained an important correlate of healthcare burden.
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