ArticleBrain sciences2026
Association of Diagonal Earlobe Crease (Frank's Sign) with Intracranial Aneurysm Rupture at Small Sizes.
Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe diagonal earlobe crease (DELC), or Frank's sign, has been associated with systemic vascular degeneration. Whether this cutaneous marker correlates with intracranial aneurysm (IA) instability remains unclear.
methodsWe conducted a hospital-based observational registry study including 186 consecutive patients with IA. DELC was dichotomized into absent/low-grade versus high-grade creases. Associations between DELC and aneurysm rupture, rupture at small sizes (<7 mm), and clinical outcome were analyzed using multivariate logistic regression models adjusted for demographic and vascular risk factors.
resultsHigh-grade DELC was significantly associated with overall aneurysm rupture (adjusted OR 3.42, 95% CI 1.39-8.41,
conclusionsFrank's sign may represent a readily observable clinical marker associated with IA instability and rupture at conventionally low-risk sizes (<7 mm). These findings support further investigation into DELC as a potential adjunct for individualized risk stratification in patients with small incidental intracranial aneurysms to prevent catastrophic subarachnoid hemorrhage.
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