ArticleBrain sciences2026
Differential Dynamic Reorganization of Functional Connectivity Based on Phase Synchrony and Amplitude Envelope Coupling During Propofol Sedation.
Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesConsciousness fluctuations involve brain network reorganization, yet the underlying neural synchronization mechanisms remain unclear. This study examined the static and dynamic characteristics of alpha-band functional connectivity during propofol sedation from two dimensions: phase synchrony and amplitude coupling.
methodsElectroencephalography data from 20 healthy volunteers across baseline, mild sedation, moderate sedation, and recovery were analyzed. Source-level signals for 68 cortical regions of interest were reconstructed using sLORETA. Dynamic functional connectivity matrices for both weighted Phase Lag Index (wPLI) and amplitude envelope correlation (AEC) were computed using 5 s sliding windows. Dynamic connectivity states were identified through clustering analysis, and state occurrence rates were compared between drowsy and responsive participants across sedation levels.
resultsStatic analysis revealed a dissociation between the two metrics: during moderate sedation, wPLI showed significant suppression in posterior parieto-occipital regions, whereas AEC exhibited widespread whole-brain coupling enhancement. Dynamic clustering identified three wPLI states and five AEC states. Critically, although the two metrics exhibited spatially distinct dynamic reconfiguration patterns, with deepening sedation, the occurrence rate of the ventral connectivity pattern in wPLI and that of the medial prefrontal pattern in AEC both increased significantly, and these two patterns showed synergistic co-occurrence. This effect was more pronounced in the drowsy subgroup, with greater increases in both patterns.
conclusionsPropofol-induced alterations in consciousness are not characterized by linear attenuation along a single neural synchrony dimension, but rather by differential reorganization of phase- and amplitude-based functional connectivity across spatial configurations and temporal dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.