Evidence map›Paper›PMID 42650877›Full record

ArticleBiomolecules2026

Placental Small Extracellular Vesicles Undetected in Cerebrospinal Fluid of Preeclamptic and Eclamptic Women.

Bryony Davies, Faheem Seedat, Lina Bergman, Catherine Cluver, Angga Wiratama Lokeswara, Michelle Ma, Morganne Wilbourne, Shuhan Jiang, Antonio Galvez, Adam Handel and 4 more

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bryony DaviesWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Faheem SeedatWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-1352-6015
Lina BergmanSAMRC Preeclampsia Extramural Research Unit, Department of Obstetrics and Gynaecology, Stellenbosch University, Cape Town 7500, South Africa.
Catherine CluverSAMRC Preeclampsia Extramural Research Unit, Department of Obstetrics and Gynaecology, Stellenbosch University, Cape Town 7500, South Africa.ORCID 0000-0002-0406-8964
Angga Wiratama LokeswaraWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-7446-8795
Michelle MaWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Morganne WilbourneWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-2780-7897
Shuhan JiangWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-6768-3040
Antonio GalvezAnesthesiology Department, Hospital Clinico Herminda Martin de Chillan, Chillan 3810525, Chile.ORCID 0009-0005-1737-7466
Adam HandelAutoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, West Wing, Oxford OX3 9DU, UK.
Andrew FowerAutoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, West Wing, Oxford OX3 9DU, UK.
Carlos EscuderoWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0001-7688-4621
Wei ZhangWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-4391-2523
Manu VatishWomen's Centre, Nuffield Department of Women's & Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-6012-2574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating small extracellular vesicles (sEVs) released from the placenta carry bioactive compounds. Placental sEVs (psEVs) have been implicated as drivers of pathology in preeclampsia, a common disorder of pregnancy. This study investigates the hypothesis that psEVs are detectable in cerebrospinal fluid (CSF) during pregnancy, and are present at higher concentrations in preeclamptic and eclamptic pregnancies. Two techniques were used to search for psEVs. Firstly, the ExoCounter assay was performed on neat CSF from normotensive, preeclamptic and eclamptic pregnancies, and non-pregnant controls (

Indexed as

EclampsiaExtracellular VesiclesPlacentaPre-EclampsiaAdultFemaleHumansMicroRNAsPregnancyMicroRNAsblood–brain barriercerebrospinal fluideclampsiaextracellular vesicleshypertensive disorders of pregnancypreeclampsia

Identifiers

PMID42650877
PMCPMC13511577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.