Evidence map›Paper›PMID 42650871›Full record

ArticleBiomolecules2026

Inherited Platelet GPIV Deficiency: First Description of a Series of Unrelated Patients with Bleeding Diathesis.

Loredana Bury, Silvia Sorrentino, Emanuela Falcinelli, Giuseppe Guglielmini, Antonietta Ferretti, Paola Concolino, Ana Sánchez-Fuentes, José Rivera, Paolo Gresele, Erica De Candia

Abstract readCase Reports
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Loredana BurySection of Internal and Cardiovascular Medicine, Hemostasis and Thrombosis Center, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
Silvia SorrentinoDipartimento di Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-7896-7815
Emanuela FalcinelliSection of Internal and Cardiovascular Medicine, Hemostasis and Thrombosis Center, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0001-6078-3041
Giuseppe GuglielminiSection of Internal and Cardiovascular Medicine, Hemostasis and Thrombosis Center, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0002-8966-7367
Antonietta FerrettiDipartimento di Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Paola ConcolinoDepartmental Unit of Molecular and Genomic Diagnostics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-0523-5744
Ana Sánchez-FuentesServicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII, 30001 Murcia, Spain.ORCID 0000-0002-4656-4771
José RiveraServicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII, 30001 Murcia, Spain.ORCID 0000-0003-4225-6840
Paolo GreseleSection of Internal and Cardiovascular Medicine, Hemostasis and Thrombosis Center, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
Erica De CandiaDipartimento di Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-0942-2819

Funding

Fondazione Telethon GMR22T1086Fundación Séneca - Agencia de Ciencia y Tecnología de la Región de Murcia 23054/GERM/25; 21920/PI/22Institute of Health Carlos III PI23/00624
6 · The paper itself

Abstract

GPIV (CD36) is a multifunctional membrane protein expressed on various cells, including platelets, where it plays a role in adhesion and activation through the interaction with its ligands, including collagen types I and III and thrombospondin 1. Inherited GPIV deficiency, historically recognized in anti-Naka alloimmunized East Asian donors, is considered asymptomatic and associated with normal platelet aggregation, although impaired adhesion under high-flow conditions has been reported. Here, we reconsider the molecular basis, epidemiology and functional consequences of GPIV deficiency and report four unrelated patients in whom heterozygous

Indexed as

Blood Platelet DisordersBlood PlateletsCD36 AntigensHemorrhageHemorrhagic DisordersPlatelet Membrane GlycoproteinsAdultFemaleHumansMalePlatelet AdhesivenessPlatelet AggregationPlatelet Glycoprotein GPIb-IX Complexadhesion receptorCD36 AntigensPlatelet Glycoprotein GPIb-IX ComplexPlatelet Membrane GlycoproteinsbleedingCD36GPIVplatelets

Identifiers

PMID42650871
PMCPMC13510369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.