Evidence map›Paper›PMID 42650858›Full record

ArticleBiomolecules2026

DNA Methylation Dynamics in

Chayeen Brotzki da Costa, Péter Németh, Péter Engelmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chayeen Brotzki da CostaDepartment of Immunology and Biotechnology, Medical School, Clinical Center, University of Pécs, 7624 Pécs, Hungary.
Péter NémethDepartment of Immunology and Biotechnology, Medical School, Clinical Center, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-3406-2010
Péter EngelmannDepartment of Immunology and Biotechnology, Medical School, Clinical Center, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-9284-4985

Funding

Ministry of Culture and Innovation of Hungary TKP2021-EGA-10University of Pecs 020_2024_PTE_RK/7, 020_2024_PTE_RK/36, 003_2025_PTE_RK/9, 003_2025_PTE_RK/10
6 · The paper itself

Abstract

The impact of epigenetic mechanisms on molecular and cellular processes of regeneration remains a less-investigated field, especially concerning earthworm segment restoration. To evaluate distinct methylated cytosines under different conditions, earthworm segments were collected: decitabine-treated and controls; anterior and posterior amputation; intact and regenerated (2- and 4-week). 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) distribution in tissues was assessed by immunohistochemistry (IHC), and in genomic DNA by dot blot. DNA-methyltransferase (DNMT) and ten-eleven translocation (TET) dioxygenase activity was determined by immuno-based colorimetry.

Indexed as

DNA MethylationOligochaetaRegeneration5-MethylcytosineAnimalsDecitabineEpigenesis, Genetic5-hydroxymethylcytosine5-MethylcytosineDecitabinedecitabineDNA methylationearthwormepigeneticsregeneration

Identifiers

PMID42650858
PMCPMC13511733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.