Evidence map›Paper›PMID 42650832›Full record

ArticleBiomolecules2026

Curcumin Nanoemulsion: Characterization and Effect on Cataracts in an In Vivo Animal Model and Ex Vivo Human Model.

Ana G Castillo-Olmos, Abigail Varela-Pérez, Hugo S García-Galindo, Joaquín A Quiroz-Mercado, Kimberly Castañeda-Gutiérrez, Carlos Amero, Enrique Rudiño-Piñera, Mizraim Morales-Mendoza, Cynthia Cano-Sarmiento

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana G Castillo-OlmosUnidad de Investigación y Desarrollo en Alimentos, Tecnológico Nacional de México-Instituto Tecnológico de Veracruz, M.A. de Quevedo 2779, Veracruz 91897, Mexico.ORCID 0000-0003-4609-9678
Abigail Varela-PérezUnidad de Investigación y Desarrollo en Alimentos, Tecnológico Nacional de México-Instituto Tecnológico de Veracruz, M.A. de Quevedo 2779, Veracruz 91897, Mexico.ORCID 0009-0009-7577-0898
Hugo S García-GalindoUnidad de Investigación y Desarrollo en Alimentos, Tecnológico Nacional de México-Instituto Tecnológico de Veracruz, M.A. de Quevedo 2779, Veracruz 91897, Mexico.ORCID 0000-0001-5805-0201
Joaquín A Quiroz-MercadoFacultad de Medicina Veterinaria y Zootecnia, Departamento de Medicina Cirugía y Zootecnia para Pequeñas Especies, Universidad Nacional Autónoma de México, Av. Universidad 3000, Ciudad de México 04510, Mexico.ORCID 0000-0002-3502-3996
Kimberly Castañeda-GutiérrezLABRMN, Centro de Investigaciones Químicas, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 2001, Chamilpa, Cuernavaca 62210, Mexico.
Carlos AmeroLABRMN, Centro de Investigaciones Químicas, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 2001, Chamilpa, Cuernavaca 62210, Mexico.ORCID 0000-0001-6300-0241
Enrique Rudiño-PiñeraLaboratorio de Bioquímica Estructural, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 2001, Chamilpa, Cuernavaca 62210, Mexico.ORCID 0000-0001-8170-6379
Mizraim Morales-MendozaOftalmología, Hospital Regional B de Alta Especialidad ISSSTE Veracruz, Av. Salvador Díaz Mirón, Veracruz 91918, Mexico.
Cynthia Cano-SarmientoUnidad de Investigación y Desarrollo en Alimentos, Tecnológico Nacional de México-Instituto Tecnológico de Veracruz, M.A. de Quevedo 2779, Veracruz 91897, Mexico.ORCID 0000-0002-9079-6748

Funding

FOODVICA SA de CV
6 · The paper itself

Abstract

Cataracts are the leading cause of reversible blindness worldwide; this condition results from the aggregation of lens proteins. Currently, surgery remains the only treatment; however, there is growing interest in non-surgical approaches, including the use of bioactive compounds incorporated into nanostructured systems designed to enhance solubility, enable controlled release, and improve bioavailability and bioactivity. Among the bioactive compounds investigated, curcumin has attracted considerable attention due to its antioxidant and anti-inflammatory properties, positioning it as a potential anticataractogenic agent. In the present study, curcumin-loaded nanoemulsion was developed via ultrasonication and characterized by average particle size, D90 percentile, ζ potential, and rheological behavior. In addition, its anti-cataract efficacy was evaluated both using an in vivo model in rats and an ex vivo model employing human cataract samples. The resulting curcumin-loaded nanoemulsion exhibited an average particle size of 152 ± 19.79 nm with a monomodal distribution, along with good physical stability over time. The nanoemulsion exhibited apparent viscosity between 30 and 25 mPa·s, at shear rate values (100 to 0 s

Indexed as

CataractCurcuminNanoparticlesAnimalsDisease Models, AnimalEmulsionsHumansLens, CrystallineMaleParticle SizeRatsViscosityCurcuminEmulsionsanimal modelcataract reversalcurcuminhuman lensesnanoemulsions

Identifiers

PMID42650832
PMCPMC13511737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.