Evidence map›Paper›PMID 42650787›Full record

ArticleBiomolecules2026

ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation.

Katherine Bronson, Milla M Reddick, Kenzie B Macnicol, Cole Bolen, Linda Hardy, Alex Lagasse, Angela K Odle, Gwen V Childs, Melanie C MacNicol, Angus M MacNicol

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Katherine BronsonDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.ORCID 0000-0002-8197-3028
Milla M ReddickDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.ORCID 0009-0006-6060-5687
Kenzie B MacnicolDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.
Cole BolenDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.ORCID 0009-0003-0229-2115
Linda HardyDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.
Alex LagasseDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.
Angela K OdleDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.ORCID 0000-0001-5017-9676
Gwen V ChildsDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.ORCID 0000-0003-3764-1373
Melanie C MacNicolDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.
Angus M MacNicolDepartment of Neuroscience, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 814, Little Rock, AR 72205, USA.ORCID 0000-0003-4812-9519

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Institutional Career DevelopmentKL2TR003108 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI ARTHUR, JOHN M., BORSHEIM, ELISABET · 2019 to 2023
$2.3M
Molecular mechanisms of pituitary plasticityR01DK139476 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI GWEN V CHILDS, MELANIE C MACNICOL · 2024 to 2026
$1.9M
J. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5M
Barton Pilot Award ,UAMS TRI Data Scholar award UL1 TR003107, KL2 TR003108 and TL1 TR003109NCATS NIH HHS KL2 TR003108NCATS NIH HHS TL1 TR003109NCATS NIH HHS UL1 TR003107NIDDK NIH HHS R01 DK139476NIH HHS RO1DK139476
6 · The paper itself

Abstract

The RNA-binding proteins Musashi1 and Musashi2 (MSI1 and MSI2) regulate stem cell function and tissue plasticity by modulating mRNA translation. While typically known as translational repressors, the MSI1 and MSI2 proteins can also act as context-dependent activators of mRNA translation, although the mechanism of MSI-mediated translational activation is unknown. Here, we identify Embryonic Lethal Abnormal Vision-like (ELAVL) proteins as essential co-regulators of MSI1-dependent translational activation. In

Indexed as

ELAV-Like Protein 1ELAV-Like Protein 4Nerve Tissue ProteinsProtein BiosynthesisRNA-Binding ProteinsXenopus ProteinsAnimalsFemaleHumansMiceOocytesPituitary GlandRibonucleoproteinsRNA, MessengerXenopus laevisELAVL1 protein, humanElavl1 protein, mouseELAVL4 protein, humanELAV-Like Protein 1ELAV-Like Protein 4Msi1h protein, mouseMsi1 protein, XenopusNerve Tissue ProteinsRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerXenopus ProteinsELAVLmRNA translationMSIoocytepituitary

Identifiers

PMID42650787
PMCPMC13510767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.