Chondroitin Sulfate Supplementation Is Associated with Body Weight Control in Ovariectomized Rats: A Multi-Omics Study of Gut Microbiota and Metabolite Profiles.

Qingshan Shen, Yanli Ma, Chunhui Zhang, Yujie Guo, Xiaojie Qin

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Qingshan ShenHenan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology, Zhang Zhongjing College of Chinese Medicine, Changjiang Road 80, Nanyang 473004, China.

Yanli MaHenan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology, Zhang Zhongjing College of Chinese Medicine, Changjiang Road 80, Nanyang 473004, China.ORCID 0000-0002-2588-5007

Chunhui ZhangKey Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Yujie GuoKey Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Xiaojie QinKey Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Funding

Agricultural Science and Technology Innovation Program of Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences CAAS-ASTIP -Q2025-IFST-11Basic and Frontier Research of Nanyang City Scientific and Technology Projec 25JCQY014China Agriculture Research System of MOF and MARA CARS-38Henan Provincial Key Science and Technology Research Project 262102310329Henan Provincial Selective Research Funding Program for Returned Scholars Studying Abroad HNLX202633Nanyang City Collaborative Innovation Major Project P. sibiricum Series Functional Food Research and Development Key Technology and Industrial Application Project 21XTCX12005

6 · The paper itself

Abstract

The prevalence of obesity among elderly women is increasing, particularly in postmenopausal populations. This exploratory study investigated the associations between chondroitin sulfate (CS) supplementation and body weight control in ovariectomized (OVX) rats, a preclinical model for postmenopausal physiology. CS supplementation was associated with significantly reduced body weight gain and preserved adipocyte morphology. CS-treated OVX rats exhibited decreased gut microbiota diversity, with reduced abundance of

Indexed as

Body WeightChondroitin SulfatesDietary SupplementsGastrointestinal MicrobiomeMetabolomeAnimalsFemaleMetabolomicsMultiomicsOvariectomyRatsRats, Sprague-DawleyChondroitin Sulfatesbody weight controlchondroitin sulfategut microbiotaovariectomized rat

Identifiers

PMID42650763

DOI10.3390/biom16081095

PMCPMC13509910

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.