Evidence map›Paper›PMID 42650753›Full record

ArticleBiomolecules2026

Cardiovascular Protection with Sulfasalazine During Doxorubicin Challenge: Evidence from Oxidative and Histologic Endpoints.

Onural Ozhan, Enes Kaya, Mehmet Hakan Tasolar, Mehmet Ertugrul Balkar, Azibe Yildiz, Feyzi Dogru, Zeynep Ulutas, Zeynep Kucukakcali, Hakan Parlakpinar

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Onural OzhanDepartment of Medical Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.ORCID 0000-0001-9018-7849
Enes KayaFaculty of Medicine, Inonu University, 44280 Malatya, Türkiye.
Mehmet Hakan TasolarDepartment of Cardiology, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.
Mehmet Ertugrul BalkarDepartment of Medical Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.ORCID 0009-0004-0878-5129
Azibe YildizDepartment of Histology and Embryology, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.ORCID 0000-0001-5686-7867
Feyzi DogruDepartment of Physiology, Faculty of Medicine, Malatya Turgut Ozal University, 44210 Malatya, Türkiye.ORCID 0000-0002-7949-9582
Zeynep UlutasDepartment of Cardiology, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.ORCID 0000-0001-6078-7480
Zeynep KucukakcaliDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.ORCID 0000-0001-7956-9272
Hakan ParlakpinarDepartment of Medical Pharmacology, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.ORCID 0000-0001-9497-3468

Funding

Inonu University TSA-2026-4452Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 1919B012223051
6 · The paper itself

Abstract

Anthracycline cardiotoxicity involves early oxidative-inflammatory injury to the myocardium and vasculature. Repurposing anti-inflammatory agents may offer pragmatic cardioprotection. The purpose of this study is to evaluate whether sulfasalazine (SSZ) mitigates doxorubicin (DOX)-induced myocardial and aortic injury in rats. Twenty-eight male Wistar albino rats were randomized to: Control (vehicle,

Indexed as

Cardiotonic AgentsCardiotoxicityDoxorubicinSulfasalazineAnimalsMaleMyocardiumOxidative StressRatsRats, WistarCardiotonic AgentsDoxorubicinSulfasalazineaortadoxorubicinmyocardial injuryoxidative stressratsulfasalazine

Identifiers

PMID42650753
PMCPMC13510095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.