ArticleAntibiotics (Basel, Switzerland)2026
Mapping the Thematic Structure and Evolution of AmpC β-Lactamase Research: A Bibliometric Analysis.
Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmpC β-lactamases are complex resistance determinants due to inducible chromosomal expression, stable derepression, plasmid-mediated dissemination, potential for co-resistance, and diagnostic interpretation challenges. Nevertheless, the scientific production, citation structure, and thematic evolution of the AmpC β-lactamase literature have not been comprehensively mapped. This study aimed to evaluate this literature using bibliometric methods.
methodsOriginal articles and reviews indexed in SCI-E and ESCI within the Web of Science Core Collection were evaluated when "AmpC" appeared in the title field. After an additional microbiological filter, 1183 documents published between 1980 and 2026 were included. Analyses were performed using R, bibliometrix, and Biblioshiny.
resultsScientific production increased from the 2000s onward. Antimicrobial Agents and Chemotherapy and Journal of Antimicrobial Chemotherapy were among the most productive and most locally cited sources, while the United States ranked first in publication output and total citation impact. The most frequent keywords were
conclusionsAmpC β-lactamase literature has broadened from an earlier emphasis on chromosomal resistance biology toward a multidimensional research field encompassing plasmid-mediated dissemination, resistance ecology, One Health-related themes, and clinical management. The recent prominence of concepts related to multidrug resistance phenotypes, the concurrent dissemination of resistance determinants, and pathogen virulence may suggest that the field is increasingly being addressed within a broader antimicrobial resistance context.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.