Evidence map›Paper›PMID 42650698›Full record

ArticleAntibiotics (Basel, Switzerland)2026

Efficacy of Inhalational Ciprofloxacin (Apulmiq) in an NHP Model of Q Fever.

Michelle Nelson, Rachel E Ireland, Francisco J Salguero, Stuart J Armstrong, Thomas R Laws, James D Blanchard, Francis Dayton, Igor Gonda, Chad W Stratilo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelle NelsonDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.
Rachel E IrelandDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.
Francisco J SalgueroUK Health Security Agency, Porton Down, Salisbury E14 4PU, UK.
Stuart J ArmstrongDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.ORCID 0000-0002-5628-0481
Thomas R LawsDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.ORCID 0000-0002-0142-9162
James D BlanchardAradigm Corporation, Hayward, CA 94545, USA.ORCID 0009-0006-6793-917X
Francis DaytonAradigm Corporation, Hayward, CA 94545, USA.ORCID 0009-0000-1791-4704
Igor GondaAradigm Corporation, Hayward, CA 94545, USA.ORCID 0000-0002-5206-794X
Chad W StratiloBio Threat Defence Section, Suffield Research Centre, Defence Research and Development Canada, Medicine Hat, AB T1A 8K6, Canada.

Funding

DRDC, Canada uk-ca-a-15-02DRDC, Canada: Chemical biological radiological (CBR) project arrangement no. uk-ca-a-15-02.
6 · The paper itself

Abstract

BACKGROUND/

objectivesQ fever, caused by

methodsMarmosets were exposed to aerosolised

resultsBoth treatments delayed fever onset and reduced disease severity versus placebo. Doxycycline prevented fever during treatment and significantly reduced bacterial loads in the lungs and spleen by Day 28. Apulmiq slightly delayed the onset of fever and reduced early bacteraemia but was less effective at bacterial clearance. Immune analyses showed macrophage activation and elevation of IFN-γ during acute infection, and adaptive immune responses by Day 28.

conclusionsInhaled Apulmiq provided partial prophylactic protection but did not achieve bacterial clearance. Doxycycline reduced bacterial burden but did not completely eliminate disease. Inhaled antibiotics may have potential for use as an alternative approach for PEP treatment, although further optimisation and investigation are needed.

Indexed as

antimicrobial therapyCallithrix jacchusCoxiella burnetiidoxycyclineInhaled antibiotic therapymarmosetrespiratory infection

Identifiers

PMID42650698
PMCPMC13509767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.