ArticleAntibiotics (Basel, Switzerland)2026
Phage Therapy Is Partially Successful in Rescuing Hornworms from
Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPhage therapy is one of the few alternatives to confront the tide of drug-resistant bacteria. Yet phage therapy is often applied knowing little more than that the therapeutic phages can grow on the infecting bacterium. The lack of convenient, inexpensive infection models slows progress in discovering principles that may improve phage therapy success. Here we explore hornworms, the larvae of hawkmoths, as a new model host for phage therapy.
methodsWe injected fifth instar hornworms with
resultsPhage treatment significantly improved survival relative to bacteria-only controls, although only modestly. Phages did not significantly affect hornworm weight gain among survivors. Differences in survival and weight among the three phage treatments were not statistically significant despite large genomic differences among the phages.
conclusionsComparing hornworms to the more commonly used waxworms, hornworms, offers additional phenotypes that can be easily assayed, but their need to be housed individually increases the effort to provide large numbers.
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