ArticleFoods (Basel, Switzerland)2026
Short-Chain Inulin and Inulin Neoseries Oligosaccharides from Red Onions Enrich Beneficial Gut Taxa and Attenuate Obesity-Related Outcomes in a Rat Model.
Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Prebiotic-mediated gut microbiota modulation is a promising approach for obesity management. Red onions have been identified as a potential source of inulin and inulin neoseries oligosaccharides. This study evaluated the in vivo effects of short-chain inulin and inulin neoseries oligosaccharides (SCIINOs) on the fecal microbiota of obese rats and assessed their potential role in obesity attenuation. Male Wistar rats were fed a high-fat diet (HFD) for 16 weeks to induce obesity, while control rats received a normal diet (ND). From weeks 16 to 24, HFD-fed obese rats were randomly assigned to four groups: SCIINOs at 0.5 g/day, SCIINOs at 1 g/day, atorvastatin (10 mg/kg/day), or no intervention. Obesity status was confirmed by increased body weight, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and higher food and energy intakes. SCIINOs were enzymatically hydrolyzed and purified by yeast treatment and chromatographic methods. After 8 weeks of SCIINO administration (1 g/day), the fecal microbiota was markedly enriched in
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