ArticleChildren (Basel, Switzerland)2026
Illness Uncertainty in Pediatric Irritable Bowel Syndrome: A Pilot Study.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesIllness uncertainty is inherent in irritable bowel syndrome (IBS); however, the factors that contribute to it and outcomes impacted by it have yet to be assessed in pediatric IBS. As such, the current longitudinal pilot study assessed the relationship between disease characteristics, illness appraisals, mood, and health-related outcomes.
methods50 youth (ages 10-18) diagnosed with IBS completed self-report measures across three timepoints. Path analysis models specifying illness uncertainty as the mediator were constructed and assessed with Mplus using Bayesian Estimation.
resultsTime-2 illness uncertainty significantly predicted time-3 depressive and anxiety symptoms, higher functional disability, and lower levels of problem- and emotion-focused coping. Exploratory indirect effects demonstrating clinical signals were also identified.
conclusionsFuture observational studies with larger samples are needed to further investigate illness appraisals' relationships with adjustment and health-related outcomes in pediatric IBS. This is a fruitful avenue to identify modifiable areas of targeted intervention.
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