ArticleChildren (Basel, Switzerland)2026
Impact of Early-Onset Sepsis on the Development and Severity of Intraventricular Hemorrhage in Premature Neonates: A Retrospective Single-Center Study.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveIntraventricular hemorrhage (IVH) is a major cause of morbidity and mortality in premature infants. Early onset neonatal sepsis (EOS) may increase the risk and severity of IVH through inflammation and hemodynamic instability. This study evaluated the association between sepsis and IVH severity.
methodsThis retrospective, single-center study included neonates diagnosed with IVH and followed in the Neonatal Intensive Care Unit of a tertiary hospital between January 2021 and December 2022. IVH grading was based on Papile's classification, and patients were categorized as low-grade (Grades I-II) or high-grade (Grade III IVH and periventricular hemorrhagic infarction [PVHI], previously referred to as Grade IV IVH). Clinical and laboratory data, including cerebrospinal fluid (CSF) and blood culture results, were analyzed. Logistic regression was used to identify factors associated with high-grade IVH.
resultsA total of 61 neonates were included, of whom 49 (80.3%) had high-grade IVH. Sepsis was detected in 33 of 49 patients (67.3%) with high-grade IVH, representing a statistically significant difference compared with the low-grade group (
conclusionsSepsis significantly increases the risk of severe (high-grade) intraventricular hemorrhage in premature infants. Early diagnosis and prompt treatment of neonatal sepsis and meningitis are crucial for preventing infection-related brain injury and improving neurodevelopmental outcomes.
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