Corbella Extra Virgin Olive Oil, Urinary Phenolic Metabolites, and Exploratory Cardiometabolic Outcomes in Healthy Young Adults: The HEVOOC Trial.

Extra virgin olive oil (EVOO) is a hallmark of the Mediterranean diet and an important dietary source of bioactive phenolic compounds, including hydroxytyrosol and tyrosol derivatives, which have been investigated in relation to cardiometabolic health. However, the potential metabolic effects of phenolic-rich EVOO in young healthy adults remain poorly characterized. In this randomized crossover trial, 28 healthy adults (29.0 ± 3.4 years) consumed either phenolic-rich EVOO or regular olive oil (OO) (0.7 g/kg/day) for 4 weeks. The cardiometabolic outcomes reported here were secondary endpoints of the trial. Anthropometric measurements, cardiometabolic biomarkers, and urinary phenolic metabolites were assessed at baseline and after each intervention period; selected phenolic metabolites were quantified in 24-h urine using targeted LC-HRMS. Treatment effects were evaluated using mixed-effects models. Compared with OO, EVOO markedly increased urinary hydroxytyrosol-glucuronide (GMR = 9.9; 95% CI: 2.0, 49.0;