Evidence map›Paper›PMID 42650227›Full record

ReviewAntioxidants (Basel, Switzerland)2026

Structure-Guided Design of Planarized Catechin Derivatives: Enhancing Antioxidant and Multifaceted Biological Activities for Therapeutic Applications.

Kiyoshi Fukuhara, Ikuo Nakanishi, Hiromu Ito, Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Masao Morita, Sakurako Okada, Akiko Ohno

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kiyoshi FukuharaDivision of Organic and Medicinal Chemistry, Showa Medical University School of Pharmacy, Shinagawa-ku, Tokyo 142-8555, Japan.ORCID 0000-0001-9677-7911
Ikuo NakanishiQuantum RedOx Chemistry Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Chiba-shi 263-8555, Japan.ORCID 0000-0001-9204-0664
Hiromu ItoQuantum RedOx Chemistry Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Chiba-shi 263-8555, Japan.
Wakana ShimizuDivision of Organic and Medicinal Chemistry, Showa Medical University School of Pharmacy, Shinagawa-ku, Tokyo 142-8555, Japan.
Yoshimi ShojiQuantum RedOx Chemistry Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Chiba-shi 263-8555, Japan.
Kei OhkuboQuantum RedOx Chemistry Team, Quantum Life Spin Group, Institute for Quantum Life Science (iQLS), National Institutes for Quantum Science and Technology (QST), Chiba-shi 263-8555, Japan.ORCID 0000-0001-8328-9249
Masao MoritaDivision of Organic and Medicinal Chemistry, Showa Medical University School of Pharmacy, Shinagawa-ku, Tokyo 142-8555, Japan.
Sakurako OkadaDivision of Organic and Medicinal Chemistry, Showa Medical University School of Pharmacy, Shinagawa-ku, Tokyo 142-8555, Japan.
Akiko OhnoDivision of Genome Safety Science, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki City 210-9501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a major driver of chronic disease, making natural polyphenols attractive scaffolds for modulating inflammation, proteostasis, and cell fate. However, green-tea catechins possess a twisted, conformationally flexible flavan-3-ol framework that limits π-conjugation, phenoxyl-radical stabilization, and productive interactions with biological targets. This review presents a structure-based framework in which conformational planarization serves as a strategy for functional amplification. Preorganization of the A/C-B inter-ring bond into a nearly coplanar arrangement reduces the conformational entropy penalty (-

Indexed as

amyloid-βantitumor activitycatechinglucosidase: antiviral activityoxidative stressplanarizationprocyanidinsilybin

Identifiers

PMID42650227
PMCPMC13509405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.