In one paragraphArticle in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Hirotsugu MiyoshiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0002-1375-5344 Sachiko OtsukiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0003-4771-9867 Kenshiro KidoDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0002-4449-1695 Ayako SumiiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0009-0005-7077-249X Tsuyoshi IkedaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0002-7277-1248 Guoqiang XiaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0009-0000-6142-7700 Yuko NodaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.
Tomomi IshiiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0009-0008-9957-2899 Satoshi KamiyaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0001-9827-1404 Soshi NarasakiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.
Pei-Lung ChenGraduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-5640-3074 Yasuko IchiharaDepartment of Anesthesiology, Kikkoman General Hospital, Chiba 278-0005, Japan.
Keiko MukaidaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0001-7255-852X Yasuo M TsutsumiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0002-1997-082X Funding
Japan Society for the Promotion of Science 22K09070Japan Society for the Promotion of Science 22K16602Japan Society for the Promotion of Science 23K08332Japan Society for the Promotion of Science 23K08382Japan Society for the Promotion of Science 25K12146
6 · The paper itselfAbstract
BACKGROUND/
objectivesMalignant hyperthermia (MH) is a life-threatening pharmacogenetic disorder of skeletal muscle primarily associated with pathogenic variants in
methodsAmong 29 CICR-positive individuals without pathogenic variants identified by gene panel testing, five patients underwent whole-exome sequencing (WES). In one family, heterozygous variants in
resultsMyotubes derived from Case 165 demonstrated enhanced sensitivity to caffeine and 4-chloro-m-cresol, elevated resting intracellular Ca
conclusionsThese findings suggest that
Indexed as
AnoctaminsCalcium ChannelsMalignant HyperthermiaMuscle Fibers, SkeletalRyanodine Receptor Calcium Release ChannelAdultCaffeineCalciumExome SequencingFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutationANO5 protein, humanAnoctaminsCaffeineCalciumCalcium ChannelsRyanodine Receptor Calcium Release ChannelRYR1 protein, humanANO5calcium homeostasisdantrolenemalignant hyperthermiaORAI3ryanodine receptorskeletal musclewhole-exome sequencing
Identifiers
PMID42650172
PMCPMC13512084
What OpenQuestion holds
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