Integrated Analysis of Multiple Databases Identifies Tissue Inhibitor of Metalloproteinase 1 Expression and Its Association with the Immune Microenvironment in Colorectal Cancer.

Yun Xie, Jun Li, Zuwei Yan, Wenguang Zhang

Abstract read

In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yun XieFaculty of Science, Inner Mongolia Agricultural University, Hohhot 010018, China.ORCID 0009-0007-9836-3203

Jun LiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China.

Zuwei YanFaculty of Science, Inner Mongolia Agricultural University, Hohhot 010018, China.

Wenguang ZhangInner Mongolia Engineering Research Center of Genomic Big Data for Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent decades, the incidence of colorectal cancer (CRC) has been rising worldwide. CRC ranks second in cancer-related mortality. The identification of reliable biomarkers for early diagnosis and prognosis prediction, along with a deeper understanding of the underlying molecular events, holds substantial promise for improving patient outcomes. The tissue inhibitor of the metalloproteinase 1 (

methodsTo probe how

resultsAccording to outcome data,

conclusions

Indexed as

Biomarkers, TumorColorectal NeoplasmsTissue Inhibitor of Metalloproteinase-1Tumor MicroenvironmentGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimatePrognosisBiomarkers, TumorTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1colorectal cancerextracellular matrixprognostic biomarkerTIMP1tumor immune microenvironment

Identifiers

PMID42650169

DOI10.3390/genes17080977

PMCPMC13511886

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.