Evidence map›Paper›PMID 42650151›Full record

ArticleGenes2026

Prenatal Substance Exposure Is Associated with Increased Placental

Tara E Samson, Donato DeIngeniis, Maki S Koyama, Roberto Bailey, Claire J Brabander, Ariadna Cilleros Portet, Corina Lesseur, Ahmed Duke Shereen, Yoko Nomura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tara E SamsonThe Graduate Center and Queens College, City University of New York, New York, NY 11367, USA.ORCID 0009-0002-5374-9755
Donato DeIngeniisThe Graduate Center and Queens College, City University of New York, New York, NY 11367, USA.
Maki S KoyamaThe Graduate Center and Queens College, City University of New York, New York, NY 11367, USA.
Roberto BaileyHunter College Campus Schools, New York, NY 10128, USA.ORCID 0009-0008-5360-7961
Claire J BrabanderThe Graduate Center and Queens College, City University of New York, New York, NY 11367, USA.
Ariadna Cilleros PortetDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Corina LesseurDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ahmed Duke ShereenThe Graduate Center and Queens College, City University of New York, New York, NY 11367, USA.ORCID 0000-0002-2293-5611
Yoko NomuraThe Graduate Center and Queens College, City University of New York, New York, NY 11367, USA.ORCID 0000-0002-2143-3257

Funding

Epigenetic susceptibility of behavioral and addictive disorders during pre/pubescence after natural disaster exposures in-uteroR01DA057310 · NIDA · QUEENS COLLEGE · PI Yoko Nomura · 2023 to 2026
$3.9M
The Evolutionary Basis of the Developmental Course and Etiologies of Anxiety and Disruptive Behaviors during Early AdolescenceR01MH131638 · NIMH · QUEENS COLLEGE · PI Yoko Nomura · 2023 to 2026
$2.8M
NIDA NIH HHS R01 DA057310NIDA NIH HHS R01DA057310NIMH NIH HHS R01 MH131638NIMH NIH HHS R01MH131638
6 · The paper itself

Abstract

BACKGROUND/

objectivesPrenatal substance exposure (PSE) to alcohol, cannabis, and other psychoactive drugs affects over 500,000 pregnancies annually in the US and is consistently associated with adverse birth and childhood outcomes, but the underlying biological mechanisms are not well-understood. Given the dopaminergic system's role in substance use and child development, this study aimed to examine and connect the effects of PSE on dopaminergic placental gene expression at birth and on striatal brain volumes in middle childhood. We hypothesized that PSE would lead to reduced dopamine receptor D1 (

methodsPSE, placental gene expression, and T1-weighted MRI data were drawn from a pilot study (

resultsUnexpectedly, children with PSE had a trend toward increased placental

conclusionsThese findings contrast prior cross-sectional work linking high-dosage PSE to smaller striatal volumes and inconsistent patterns of dopaminergic gene expression, suggesting potential compensatory placental mechanisms reflected in biological outcomes across child development.

Indexed as

Gray MatterPlacentaPrenatal Exposure Delayed EffectsReceptors, Dopamine D1ChildCorpus StriatumFemaleGene ExpressionHumansMagnetic Resonance ImagingMalePilot ProjectsPregnancyDRD1 protein, humanReceptors, Dopamine D1Developmental Origins of Health and Diseasedopaminergic systemDRD1gray-matter volumehormesisplacental gene expressionprenatal substance exposurestriatum

Identifiers

PMID42650151
PMCPMC13512815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.