Evidence map›Paper›PMID 42650100›Full record

ArticleGenes2026

KRAS Mutation Detection by Real-Time and Digital PCR in Tumor Tissue and Plasma and Its Association with Survival in Stage II-IV Colorectal Cancer: A Kazakhstan Cohort Study.

Timur Nasrytdinov, Dilyara Kaidarova, Venera Israilova, Saken Khaidarov, Bayan Nurgaliyeva, Slu Izmailova, Gulmira Rapilbekova, Marat Rabandiyarov, Bibigul Abdygalyk, Askar Aidarov and 2 more

Abstract read
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Timur NasrytdinovOperating Theatre, Kazakh Institute of Oncology and Radiology, 91 Abay Ave., Almaty 050000, Kazakhstan.
Dilyara KaidarovaDepartment of Oncology, Asfendiyarov Kazakh National Medical University, Tole-Bi Street 94, Almaty 050012, Kazakhstan.ORCID 0000-0002-0969-5983
Venera IsrailovaDepartment of Cardiology, City Cardiology Centre, Faculty of Medicine, University of International Business, Abay Ave. 8A, Almaty 050010, Kazakhstan.
Saken KhaidarovDepartment of Molecular Biology and Medical Genetics, Asfendiyarov Kazakh National Medical University, Zheltoksan Street 37A, Almaty 050004, Kazakhstan.ORCID 0000-0001-7770-8427
Bayan NurgaliyevaDepartment of Propaedeutics of Internal Medicine, Asfendiyarov Kazakh National Medical University, 94 Tole Bi Str., Almaty 050012, Kazakhstan.ORCID 0000-0003-2555-8644
Slu IzmailovaDepartment of General Paediatrics, Children's City Clinical Hospital No. 2 of Almaty, Microdistrict 2, Building 54, Almaty 050062, Kazakhstan.ORCID 0000-0001-8829-3757
Gulmira RapilbekovaDepartment of Gynaecology, University Medical Centre (UMC), Kerey and Zhanibek Khandar Str. 5/1, Astana 010000, Kazakhstan.
Marat RabandiyarovDepartment of General Paediatrics, Children's City Clinical Hospital No. 2 of Almaty, Microdistrict 2, Building 54, Almaty 050062, Kazakhstan.ORCID 0000-0003-3471-5488
Bibigul AbdygalykDepartment of General Paediatrics, Children's City Clinical Hospital No. 2 of Almaty, Microdistrict 2, Building 54, Almaty 050062, Kazakhstan.
Askar AidarovDepartment of Oncology, Asfendiyarov Kazakh National Medical University, Tole-Bi Street 94, Almaty 050012, Kazakhstan.ORCID 0000-0001-5081-1264
Daulet AidarovDepartment of Oncology, Kazakh-Russian Medical University, Abylay Khan Avenue 51/53, Almaty 050000, Kazakhstan.
Aray AidarovaDepartment of Oncology, Kazakh-Russian Medical University, Abylay Khan Avenue 51/53, Almaty 050000, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesColorectal cancer (CRC) is molecularly heterogeneous, and the

methodsWe studied 332 patients with morphologically confirmed stage II-IV colorectal adenocarcinoma.

results

conclusionsThis first Kazakhstani series places

Indexed as

AdenocarcinomaColorectal NeoplasmsMutationProto-Oncogene Proteins p21(ras)AdultAgedBiomarkers, TumorCohort StudiesFemaleHumansKazakhstanMaleMiddle AgedNeoplasm StagingPrognosisReal-Time Polymerase Chain ReactionBiomarkers, TumorKRAS protein, humanProto-Oncogene Proteins p21(ras)circulating tumor DNAcolorectal cancerdigital PCRKazakhstanKRASliquid biopsymolecular oncologyoverall survivalprecision medicinereal-time PCR

Identifiers

PMID42650100
PMCPMC13512796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.