ArticleGenes2026
Major Histocompatibility Complex Genomic Regions as Candidates for Reproductive Success in Cattle: From GWAS to Post-GWAS Analysis.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundThe major histocompatibility complex (MHC) is a well-known gene complex that plays a fundamental role in immune recognition; however, its influence on reproductive processes in cattle is not yet fully established, particularly regarding how it modulates the female response to the embryo. Therefore, this study aimed to investigate the relationship between MHC genes and reproductive processes in cattle and to identify potential molecular targets involved in these mechanisms.
methodsData from four studies identified through a systematic review were integrated. MHC genes associated with reproduction were identified, neighboring genomic regions were explored to detect candidate genes and transcription factors, and biological process networks were constructed using differentially expressed genes associated with cattle.
resultsThe integrated analysis led to the identification of six MHC genes associated with reproduction, along with 54 candidate genes from genome-wide association studies and 46 from transcriptomic studies located in neighboring regions. Among these,
conclusionsThis work integrates currently available evidence and highlights potential molecular targets that can be explored in cattle breeding and reproductive biology, associating MHC genes with these roles and advancing innovative perspectives in the field of molecular genetics.
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