Swimming Upstream to Understand Congenital Anomalies of the Kidney and Urinary Tract: Zebrafish Models for Developmental Biology, Disease Mechanisms, and Functional Interpretation of Genetic Variation.

Zachary W Nurcombe, Lina Mougharbel, Thomas M Kitzler

Abstract readReview

In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zachary W NurcombeDepartment of Human Genetics, McGill University, 845 Sherbrooke St. W, Montreal, QC H3A 0G4, Canada.ORCID 0009-0002-5722-0971

Lina MougharbelResearch Institute of the McGill University Health Centre, 1001 Blvd. Décarie, Montreal, QC H4A 0B1, Canada.ORCID 0009-0009-9121-2853

Thomas M KitzlerDepartment of Human Genetics, McGill University, 845 Sherbrooke St. W, Montreal, QC H3A 0G4, Canada.ORCID 0009-0006-1537-5237

Funding

Fonds de Recherche du Québec - Santé 347103Kidney Foundation of Canada 24KHRG-1255923

6 · The paper itself

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of pediatric chronic kidney disease (CKD) and comprise a heterogeneous group of developmental disorders with a substantial genetic contribution. Advances in next-generation sequencing have facilitated the identification of numerous candidate genes and rare variants associated with CAKUT. However, establishing causality and defining the biological functions of implicated genes remain major challenges. Functional validation is therefore essential to bridge the gap between gene discovery and mechanistic understanding, enabling the interpretation of genetic variation within the context of kidney development and disease. The zebrafish (

Indexed as

KidneyUrinary TractUrogenital AbnormalitiesVesico-Ureteral RefluxZebrafishAnimalsDisease Models, AnimalGene Expression Regulation, DevelopmentalGenetic VariationHumansOrganogenesisCAKUTcongenital anomalies of the kidney and urinary tractdisease modellingfunctional genomicskidney morphogenesismonogenic diseasepronephrosrenal developmentvariant interpretationzebrafish

Identifiers

PMID42650060

DOI10.3390/genes17080867

PMCPMC13536465

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.